Protein Alignment CG8170 and CFI

DIOPT Version :10

• Sequence 1: NP_610441.2
• Gene: CG8170 / 35908
• FlyBaseID: FBgn0033365
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001362207.1
• Gene: CFI / 3426
• HGNCID: 5394
• Length: 601
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 116/536 - (21%)
• Similarity: 184/536 - (34%)
• Gaps: 165/536 - (30%)

  Fly   377 ITALPQQRPQRGFYFGDTEFRTGPPAPVRQFGPQKNFQEYVGPSEYQGTRKSRYYPYKSSRSPRV 441
            :..||.|.|:.|.....|..|:.|     .:..||:. |.:.|    ||:
Human    60 VCKLPYQCPKNGTAVCATNRRSFP-----TYCQQKSL-ECLHP----GTK--------------- 99

  Fly   442 VFPTNDNVGTTGPSGPAGSSGPSGN----GV-----YFSDNIAF--------RDQNFGINELAAV 489
             |..|   ||....|....|...||    |:     ...|...|        |:.|....:|...
Human   100 -FLNN---GTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQ 160

  Fly   490 Q--DVRNDYSLQDLD----------------SASEATSSPQSASTFKEKVDITTDTE-------- 528
            |  |.:..:.|.||.                |.:|.|.:.:....:::..|:...|:
Human   161 QGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDD 225

  Fly   529 ---------------------------------CQHRGGTCEFFLGCWLSGGLI--QGTCDGLLR 558
                                             ||.:|..|:       ||..|  |..|:|.:.
Human   226 FFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCK-------SGVCIPSQYQCNGEVD 283

  Fly   559 --------GCC---HRTAKS-ANLGSSDFVGNAVDLTDLPQKNYGPVNNEPSCGISLAKQTAQRR 611
                    ||.   |.|.:. |::...:......|: |..::....:..:.|||:.......::|
Human   284 CITGEDEVGCAAARHPTIQGFASVTQEETEILTADM-DAERRRIKSLLPKLSCGVKNRMHIRRKR 347

  Fly   612 IVGGDDAGFGSFPWQAYIRIGSS-RCGGSLISRRHVVTAGHCV-ARATPR-QVHVTLGDYVINSA 673
            ||||..|..|..|||..|:..|. .|||..|....::||.||: |..|.| |:..|:.|::....
Human   348 IVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDL 412

  Fly   674 VEPLPAYTFGVRRIDVHPYFKFTPQADRFDISVLTLERTVH----FMPHIAPICLP------EKN 728
            ...:..|   |.||..|.  .:.....:.||:::.:::..:    .:|...|.|:|      :.|
Human   413 KRIVIEY---VDRIIFHE--NYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPN 472

  Fly   729 EDFLGKFGWAAGWGALNPGSRLRPKTLQAVDVPVIENRICERWHRQNGINVVIYQEMLCAGYRNG 793
            :..:     .:|||......|:  .:||..:|.:|.|  |.:::.    |....:||.||
Human   473 DTCI-----VSGWGREKDNERV--FSLQWGEVKLISN--CSKFYG----NRFYEKEMECA----- 519

  Fly   794 GKDSCQGDSGGPLMHD 809
              |.|.....|...||
Human   520 --DCCSVAQAGVQWHD 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	57/211 (27%)
CFI	NP_001362207.1	FIMAC	43..108	CDD:214493	18/76 (24%)
		SR	114..215	CDD:214555	18/100 (18%)
		LDLa	224..256	CDD:238060	0/31 (0%)
		Ldl_recept_a	257..293	CDD:395011	10/42 (24%)
		Tryp_SPc	348..>519	CDD:238113	50/188 (27%)