DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8170 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_610441.2	Gene:	CG8170 / 35908	FlyBaseID:	FBgn0033365	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	930	Identity:	223/930 - (23%)
Similarity:	333/930 - (35%)	Gaps:	261/930 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ASRSTRNTWRWSRLALAVSLFAYCCCASSAATPTTSVTTAALLSGHQLLPW----QTAAATAATT 75
            |.|..|:..|::.|.|.:                     |||.|...:| |    ..|..|.:..
  Rat    47 AKRKDRDYVRFTPLLLVL---------------------AALASAGVML-WYFLGYKAEVTISQV 89

  Fly    76 PSTARNLYAPH--QSFSRHDDISFKDLRQRSDGTVVQSFGSYRTARQFGGYSTTAQRRSDPAVEI 138
            .|.:..:...|  |..:|.:.|:|:....::.....:...|.|....:...|..|         .
  Rat    90 YSGSLRVLNRHFSQDLARRESIAFRTETAKAQKMFQELVASTRLGTYYNSSSIYA---------F 145

  Fly   139 IPAPSV-------ELPQGELITVPKQLVPTM--PENVTRQGRRRNYMYIPLQTEGENGSAALLQL 194
            ...|.:       ::|:.:.:|:..::|..:  .|.::......:|     :||.|.....|:.|
  Rat   146 GEGPLICFFWFILDIPEYQRLTLSPEVVRELLVGELLSNSSALASY-----RTEYEVDPEGLVIL 205

  Fly   195 RPS------RNATLSALGPPADGVAAVAHEFGADLATQG-----SGPEQPPLALELGPERTERSD 248
            ..|      .|:||............|....|.|..|..     .|||...|.::|...|.:..|
  Rat   206 EASVNDIVVLNSTLGCYRYSYVNPGQVLRLRGPDQQTTSCLWHLQGPEDLMLKVQLEWTRVDCRD 270

  Fly   249 LMAAASSTDKLE------------------------------------YAEPENTS-RRVGFQFP 276
            .:|...:...||                                    :.:|...| :.|.||..
  Rat   271 RVAMYDAAGPLEKRLITSVYGCSRQEPVMEVLASGSVMAVVWKKGLHSFYDPFLLSVKSVAFQDC 335

  Fly   277 SYSLKPASPFHPQAYREDNPIFGDTSAGGYEPQPYSEDASPVPPPTQYEQHETRHTRQLYFDSDT 341
            ..:|.......||.:.. .|         |.|..||       |.|....|.|
  Rat   336 QVNLTLEGRLDPQGFLR-TP---------YYPSYYS-------PSTHCSWHLT------------ 371

  Fly   342 ASSSFEFPGLVSNSKPHGLKLYRDDVT----KFGDINGPITALPQQRPQRGFYFGDTEFRTGPPA 402
                  .|.|     .:||.|:.|...    |:..:......:.|.|...||
  Rat   372 ------VPSL-----DYGLALWFDAYALRRQKYNLLCTQGQWMIQNRRLCGF------------- 412

  Fly   403 PVRQFGPQKNFQEYVGPSEYQGTRKSRYYPYKSSRSPRVVFPTNDNVGTTGP-----------SG 456
                    :..|.|           :...|..:|....:.|  ...:..|||           |.
  Rat   413 --------RTLQPY-----------AERIPVVASDGITINF--TSQISLTGPGVQVYYSLYNQSD 456

  Fly   457 PA-GSSGPSGNGVYFSDNIAFRDQNFGINELAAVQDVRNDYSLQDLDSASEATSSPQSASTFKEK 520
            |. |....|.||:........:|...|::|...|  .|..:..|:   .|...|.|:......:.
  Rat   457 PCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCV--CRAMFQCQE---DSTCISLPRVCDRQPDC 516

  Fly   521 VDITTDTECQHRGGTCEFFLGCWLSGGLIQGTCDGLLRGCCHRTAKSANLGSSDFVGNAVDLTDL 585
            ::.:.:.:|| .|..|          |.....|:.  |.|..:.....:       |.| |..|
  Rat   517 LNGSDEEQCQ-EGVPC----------GTFTFQCED--RSCVKKPNPECD-------GQA-DCRD- 559

  Fly   586 PQKNYGPVNNEPSCGISLAKQTAQRRIVGGDDAGFGSFPWQAYIRI-GSSRCGGSLISRRHVVTA 649
                 |.......||:    |....|||||..:..|.:||||.::| |...|||:||:.|.|:||
  Rat   560 -----GSDEEHCDCGL----QGPSSRIVGGAMSSEGEWPWQASLQIRGRHICGGALIADRWVITA 615

  Fly   650 GHCV---ARATPRQVHVTLGDYVINSAVEPLPA-YTFGVRRIDVHPYFKFTPQADRFDISVLTLE 710
            .||.   :.|:||...|.||....||.   .|. .:|.|.|:.:|||.:  ..:..:|:::|.|:
  Rat   616 AHCFQEDSMASPRLWTVFLGKMRQNSR---WPGEVSFKVSRLFLHPYHE--EDSHDYDVALLQLD 675

  Fly   711 RTVHFMPHIAPICLPEKNEDF-LGKFGWAAGWGAL---NPGSRLRPKTLQAVDVPVIENRICERW 771
            ..|.:...:.|:|||.::..| .|:..|..||||.   .|||    .|||.|||.:|...:|...
  Rat   676 HPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPGS----STLQKVDVQLIPQDLCNEA 736

  Fly   772 HRQNGINVVIYQ---EMLCAGYRNGGKDSCQGDSGGPLM-HDKNGRWYLIGVVSAGYSCASRGQP 832
            :|        ||   .|||||||.|.||:|||||||||: .:.:|||:|.|:||.|..|   |:|
  Rat   737 YR--------YQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGC---GRP 790

  Fly   833 ---GIYHSVSKTVDWVSYVV 849
               |:|..|::.|:|:..|:
  Rat   791 NFFGVYTRVTRVVNWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	611..845	CDD:214473	101/249 (41%)
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	101/249 (41%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699	15/105 (14%)
		LDLa	459..489	CDD:238060	7/29 (24%)
		LDLa	495..525	CDD:238060	4/32 (13%)
		Ldl_recept_a	529..566	CDD:278486	10/62 (16%)
		Tryp_SPc	576..806	CDD:214473	101/249 (41%)
		Tryp_SPc	577..809	CDD:238113	101/251 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910