Protein Alignment CG8170 and HGFAC

DIOPT Version :10

• Sequence 1: NP_610441.2
• Gene: CG8170 / 35908
• FlyBaseID: FBgn0033365
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001284368.1
• Gene: HGFAC / 3083
• HGNCID: 4894
• Length: 662
• Species: Homo sapiens
• Alignment Length: 714
• Identity: 188/714 - (26%)
• Similarity: 262/714 - (36%)
• Gaps: 172/714 - (24%)

  Fly   196 PSRNATLSALGPPADGVAAVAHEFGADLATQGSGPEQ---PPLALELGPERTERSDLMAAASSTD 257
            |..|||.:. ..|...|.:|..|..|..|.:..||:.   ||      |.|
Human    45 PEPNATATP-AIPTILVTSVTSETPATSAPEAEGPQSGGLPP------PPR-------------- 88

  Fly   258 KLEYAEPENTSRRVGFQFPSYSLKPASPFHPQAYREDNPIFGDTSAGGYEPQPYSEDASPVPPPT 322
                |.|.::|                   |||                  |..:||..|...|.
Human    89 ----AVPSSSS-------------------PQA------------------QALTEDGRPCRFPF 112

  Fly   323 QY------------EQHE----TRHTRQLYFDSDTASSSFEFPGLVSNSKPHGLKLYRDDVTKFG 371
            :|            ..|.    |.|.    :|.|.|     :...|..:.|.|.....|......
Human   113 RYGGRMLHACTSEGSAHRKWCATTHN----YDRDRA-----WGYCVEATPPPGGPAALDPCASGP 168

  Fly   372 DINGPITALPQQRPQ-------RGF---------YFGDT--EFRTGPP--APVRQFGPQKNFQEY 416
            .:||. :....|.||       |.|         .|.:|  |:..|..  |.||| |..:..:.:
Human   169 CLNGG-SCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQ-GHVEQCECF 231

  Fly   417 VGPSEYQGTRKSRYY--PYKSSRSPRVVFPTNDNVGTTGPSGPAGSSG------PS-----GNGV 468
            .|.:..:|||.:...  |..:..:..::..|    |||..:.|.|.:|      |.     |||.
Human   232 GGRTWCEGTRHTACLSSPCLNGGTCHLIVAT----GTTVCACPPGFAGRLCNIEPDERCFLGNGT 292

  Fly   469 YFSDNIAFRDQNFGINELAAVQDVRNDYSLQDLDSASEATSSPQSASTFKEKVDITTDTECQHRG 533
            .:. .:|....: |::.||...|:.  |....:||...|.........:....|......|....
Human   293 GYR-GVASTSAS-GLSCLAWNSDLL--YQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVK 353

  Fly   534 GTCEFFLGCWLSGGLIQGTCDGLLRG--CCHRTAKSANLGSSDFVGNAVDLTDLPQKNYGPVN-N 595
            .:...:..|.|.      .||....|  ...|...|.:|           |..||:    |.: .
Human   354 DSALSWEYCRLE------ACDLETEGRESLTRVQLSPDL-----------LATLPE----PASPG 397

  Fly   596 EPSCGISLAKQTAQR-RIVGGDDAGFGSFPWQAYIRIGSSRCGGSLISRRHVVTAGHCVARATPR 659
            ..:||....|:|..| ||:||..:..||.||.|.|.||.|.|.|||:....||:|.||.:.:.||
Human   398 RQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPR 462

  Fly   660 -QVHVTLGDYVINSAVEPLPAYTFGVRR-IDVHPYFKFTPQADRFDISVLTL----ERTVHFMPH 718
             .|.|.||.:..|...:  ...|||:.: |....|..|.| :|. |:.::.|    :|.......
Human   463 DSVSVVLGQHFFNRTTD--VTQTFGIEKYIPYTLYSVFNP-SDH-DLVLIRLKKKGDRCATRSQF 523

  Fly   719 IAPICLPEKNEDF-LGKFGWAAGWGALNPGSRLRPKTLQAVDVPVIENRICERWHRQNGINVVIY 782
            :.||||||....| .|.....||||.|:........:|:...||::.:..|.   ........|.
Human   524 VQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCS---SPEVYGADIS 585

  Fly   783 QEMLCAGYRNGGKDSCQGDSGGPLMHDKNGRWYLIGVVSAGYSCASRGQPGIYHSVSKTVDWVS 846
            ..||||||.:...|:|||||||||..:|||..||.|::|.|..|....:||:|..|:..|||::
Human   586 PNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWIN 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	89/240 (37%)
HGFAC	NP_001284368.1	PRK14954	<32..>100	CDD:184918	22/116 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..102		16/98 (16%)
		FN2	102..148	CDD:128373	11/54 (20%)
		EGF_CA	162..197	CDD:238011	8/35 (23%)
		FN1	200..240	CDD:238018	10/40 (25%)
		EGF_CA	245..278	CDD:238011	8/36 (22%)
		Kringle	286..367	CDD:395005	16/90 (18%)
		Tryp_SPc	415..650	CDD:238113	89/242 (37%)