Protein Alignment CG8170 and F12

DIOPT Version :10

• Sequence 1: NP_610441.2
• Gene: CG8170 / 35908
• FlyBaseID: FBgn0033365
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_000496.2
• Gene: F12 / 2161
• HGNCID: 3530
• Length: 615
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 96/279 - (34%)
• Similarity: 134/279 - (48%)
• Gaps: 28/279 - (10%)

  Fly   585 LPQKNYGP---VNNEP-SCGISLAKQ-TAQRRIVGGDDAGFGSFPWQAYIRIGSSRCGGSLISRR 644
            ||.|...|   ..|.| |||..|.|. ::..|:|||..|..|:.|:.|.:..|.|.|.||||:..
Human   341 LPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPC 405

  Fly   645 HVVTAGHCVA-RATPRQVHVTLGDYVINSAVEPLPAYTFGVRRIDVHPYFKFTPQADRFDISVLT 708
            .|:||.||:. |..|..:.|.||....|.:.|  |..|..||...:|.  .|:|.:.:.|:::|.
Human   406 WVLTAAHCLQDRPAPEDLTVVLGQERRNHSCE--PCQTLAVRSYRLHE--AFSPVSYQHDLALLR 466

  Fly   709 LERTVH-----FMPHIAPICLP----EKNEDFLGKFGWAAGWGALNPGSRLRPKTLQAVDVPVIE 764
            |:....     ..|::.|:|||    ..:|..|.:   .||||....|:......||...||.:.
Human   467 LQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQ---VAGWGHQFEGAEEYASFLQEAQVPFLS 528

  Fly   765 NRICERWHRQNGINVVIYQEMLCAGYRNGGKDSCQGDSGGPLMHDKNG---RWYLIGVVSAGYSC 826
               .||....:.....|...|||||:..||.|:|||||||||:.:...   |..|.|::|.|..|
Human   529 ---LERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGC 590

  Fly   827 ASRGQPGIYHSVSKTVDWV 845
            ..|.:||:|..|:..:.|:
Human   591 GDRNKPGVYTDVAYYLAWI 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	84/247 (34%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:394967
		Kringle	217..295	CDD:395005
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..359		6/17 (35%)
		Tryp_SPc	373..612	CDD:238113	84/247 (34%)