Protein Alignment CG8170 and TMPRSS6

DIOPT Version :10

• Sequence 1: NP_610441.2
• Gene: CG8170 / 35908
• FlyBaseID: FBgn0033365
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001275929.1
• Gene: TMPRSS6 / 164656
• HGNCID: 16517
• Length: 824
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 146/519 - (28%)
• Similarity: 210/519 - (40%)
• Gaps: 126/519 - (24%)

  Fly   423 QGTRKSRYYPYKSSRSPRVVFPTNDNVGTTGPSGPAGSSGPSGNGVYFSDNIAFRDQNFGINELA 487
            ||...:.|:|  |..||:    |:.:...|.||...|.:      ::| |..|.|.|.:.:....
Human   339 QGVLSTPYFP--SYYSPQ----THCSWHLTVPSLDYGLA------LWF-DAYALRRQKYDLPCTQ 390

  Fly   488 AVQDVRND--YSLQDLDSASEATSSPQSAS---TFKEKVDITTDTECQHRG-----GTC--EFFL 540
            ....::|.  ..|:.|...:|......:|.   .|..::.:|......|.|     ..|  ||.
Human   391 GQWTIQNRRLCGLRILQPYAERIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFL- 454

  Fly   541 GCWLSGGLIQGTCDGLL--------RGC-CHRTAKSAN-----------------LGSSD----- 574
             |.:: ||....|||:.        |.| |..|.:...                 |..||
Human   455 -CSVN-GLCVPACDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQ 517

  Fly   575 -------FVGNAVDLTDLPQKN----------YGPVNNEPSCGISLAKQTAQRRIVGGDDAGFGS 622
                   |.....|.:.:.:.|          .|.......||:    |....|||||..:..|.
Human   518 EGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGL----QGPSSRIVGGAVSSEGE 578

  Fly   623 FPWQAYIRI-GSSRCGGSLISRRHVVTAGHCV---ARATPRQVHVTLGDYVINSAVEPLPA-YTF 682
            :||||.::: |...|||:||:.|.|:||.||.   :.|:.....|.||....||.   .|. .:|
Human   579 WPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSR---WPGEVSF 640

  Fly   683 GVRRIDVHPYFKFTPQADRFDISVLTLERTVHFMPHIAPICLPEKNEDF-LGKFGWAAGWGALNP 746
            .|.|:.:|||.:  ..:..:|:::|.|:..|.....:.|:|||.::..| .|...|..|||||..
Human   641 KVSRLLLHPYHE--EDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALRE 703

  Fly   747 GSRLR----------------------PKTLQAVDVPVIENRICERWHRQNGINVVIYQ---EML 786
            |: ||                      ...||.|||.:|...:|...:|        ||   .||
Human   704 GA-LRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQDLCSEVYR--------YQVTPRML 759

  Fly   787 CAGYRNGGKDSCQGDSGGPLM-HDKNGRWYLIGVVSAGYSCASRGQPGIYHSVSKTVDWVSYVV 849
            |||||.|.||:|||||||||: ...:|||:|.|:||.|..|......|:|..::..:.|:..||
Human   760 CAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVV 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	94/265 (35%)
TMPRSS6	NP_001275929.1	SEA	77..>134	CDD:460188
		CUB	326..440	CDD:238001	24/113 (21%)
		LDLa	450..480	CDD:238060	9/32 (28%)
		LDLa	486..516	CDD:238060	3/29 (10%)
		Ldl_recept_a	520..557	CDD:395011	4/36 (11%)
		Tryp_SPc	568..822	CDD:238113	94/267 (35%)