DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13744 and TMPRSS11D

DIOPT Version :9

Sequence 1:	NP_610439.1	Gene:	CG13744 / 35906	FlyBaseID:	FBgn0033363	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_004253.1	Gene:	TMPRSS11D / 9407	HGNCID:	24059	Length:	418	Species:	Homo sapiens

Alignment Length:	301	Identity:	93/301 - (30%)
Similarity:	138/301 - (45%)	Gaps:	42/301 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 SPSSPLANLVDYGKLKLNLNSLPKRIMLRRRDDNELLNPKPECGVPRTAQNTLQKRIIGGRPAQF 150
            :||:.:.:|.|....                  |.|:|   |||.........::||:||..|:.
Human   152 NPSTEITSLTDQAAA------------------NWLIN---ECGAGPDLITLSEQRILGGTEAEE 195

  Fly   151 AEYPWQAHIRIAE-YQCGGVLISANMVATAAHCIQ-QAHLADITVYLGELDTQDLGHIHEPLPVE 213
            ..:|||..:|:.. :.|||.||:...:.|||||.: .::..|.....|         |....|..
Human   196 GSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSG---------ISTTFPKL 251

  Fly   214 KHGVLQKIIHPRFNFRMTQPDRYDIALLKLAQPTSFTEHILPICLPQYPIRL-IGRKGLIAGWGK 277
            :..|...:||.  |::....:. ||||::|....:||:.|..:|||.....: .|....:.|||.
Human   252 RMRVRNILIHN--NYKSATHEN-DIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGA 313

  Fly   278 TEAHMGHAGTNMLQVASVPIITTLDCIRWHESKQINVEIKAEMFCAGHSDGHMDACLGDSGGPLV 342
            .| :.||....:.| ..|.||:...|...|   ..|..|.:.|.|||...|.:|||.||||||||
Human   314 QE-YAGHTVPELRQ-GQVRIISNDVCNAPH---SYNGAILSGMLCAGVPQGGVDACQGDSGGPLV 373

  Fly   343 IKERGR-FVLVGITSAGFGCGVDHQPGIYHNVQKTVRWIQE 382
            .::..| :.:|||.|.|..||:..:||:|..|...:.||::
Human   374 QEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQ 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13744	NP_610439.1	Tryp_SPc	141..380	CDD:214473	81/242 (33%)
CG13744	NP_610439.1	Tryp_SPc	142..383	CDD:238113	82/245 (33%)
TMPRSS11D	NP_004253.1	SEA	48..143	CDD:279699
		Tryp_SPc	186..412	CDD:214473	81/242 (33%)
		Tryp_SPc	187..415	CDD:238113	82/245 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4261
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960