DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13744 and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_610439.1	Gene:	CG13744 / 35906	FlyBaseID:	FBgn0033363	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	441	Identity:	123/441 - (27%)
Similarity:	186/441 - (42%)	Gaps:	107/441 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ICQSSPSQANILNTLLG----------------VPAECVHQSGVWPCKLSFSC-----WLQGGKH 58
            :|.|...:|..:...||                :.::| ..||: .|..|.:|     |..|..|
Human   113 VCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKC-SNSGI-ECDSSGTCINPSNWCDGVSH 175

  Fly    59 AKG------C----GSNKWLFSCCVAETQ----HPHQQQHHSPSSPLANLVDYGK---------- 99
            ..|      |    |.|   |...|..:|    ||..|...:.:...|...|.|.
Human   176 CPGGEDENRCVRLYGPN---FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGI 237

  Fly   100 ---------LKLNLNS----LPKRIMLRRRDDNELLNPKP-------ECGVPRTAQNTLQKRIIG 144
                     :|||.::    :.|::.     .::..:.|.       .|||  ...::.|.||:|
Human   238 VDDSGSTSFMKLNTSAGNVDIYKKLY-----HSDACSSKAVVSLRCIACGV--NLNSSRQSRIVG 295

  Fly   145 GRPAQFAEYPWQAHIRIAE-YQCGGVLISANMVATAAHCIQQA-----HLADITVYLGELDTQDL 203
            |..|....:|||..:.:.. :.|||.:|:...:.|||||:::.     |.   |.:.|.| .|..
Human   296 GESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW---TAFAGIL-RQSF 356

  Fly   204 GHIHEPLPVEKHGVLQKIIHPRFNFRMTQPDRYDIALLKLAQPTSFTEHILPICLPQYPIRLIGR 268
            ........|||     .|.||.::   ::....||||:||.:|.:|.:.:.|:|||. |..::..
Human   357 MFYGAGYQVEK-----VISHPNYD---SKTKNNDIALMKLQKPLTFNDLVKPVCLPN-PGMMLQP 412

  Fly   269 KGL--IAGWGKTEAHMGHAGTNMLQVASVPIITTLDCIRWHESKQI--NVEIKAEMFCAGHSDGH 329
            :.|  |:|||.|| ..|.. :.:|..|.|.:|.|..|    .|:.:  |: |...|.|||...|:
Human   413 EQLCWISGWGATE-EKGKT-SEVLNAAKVLLIETQRC----NSRYVYDNL-ITPAMICAGFLQGN 470

  Fly   330 MDACLGDSGGPLVIKERGRFVLVGITSAGFGCGVDHQPGIYHNVQKTVRWI 380
            :|:|.||||||||..:...:.|:|.||.|.||...::||:|.||.....||
Human   471 VDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13744	NP_610439.1	Tryp_SPc	141..380	CDD:214473	85/248 (34%)
CG13744	NP_610439.1	Tryp_SPc	142..383	CDD:238113	86/249 (35%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060	10/36 (28%)
		SRCR_2	190..283	CDD:292133	17/100 (17%)
		Tryp_SPc	292..521	CDD:214473	85/248 (34%)
		Tryp_SPc	293..524	CDD:238113	86/249 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910