DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13744 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_610439.1	Gene:	CG13744 / 35906	FlyBaseID:	FBgn0033363	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	341	Identity:	104/341 - (30%)
Similarity:	155/341 - (45%)	Gaps:	49/341 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SNKWLFSCC-------VAETQHPHQQQHHSPSSPLANLVDYGK------LKLNLNSLPKRIMLRR 115
            :..| ||.|       :|||  ..:|..:| |.|....|:.|.      :::..||...|:   |
Human   120 TGNW-FSACFDNFTEALAET--ACRQMGYS-SKPTFRAVEIGPDQDLDVVEITENSQELRM---R 177

  Fly   116 RDDNELLNPK------PECGVPRTAQNTLQKRIIGGRPAQFAEYPWQAHIRI-AEYQCGGVLISA 173
            ......|:..      ..||     ::....|::|...|....:|||..|:. .::.|||.::..
Human   178 NSSGPCLSGSLVSLHCLACG-----KSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDP 237

  Fly   174 NMVATAAHCIQQAHLADITVYLGELDTQDLGHIHEPLPVEKHGVLQKIIHPRFNFRMTQPDRYDI 238
            :.|.|||||.:: | .|:..:.....:..||.. ..|.|.|..:::        |....|...||
Human   238 HWVLTAAHCFRK-H-TDVFNWKVRAGSDKLGSF-PSLAVAKIIIIE--------FNPMYPKDNDI 291

  Fly   239 ALLKLAQPTSFTEHILPICLPQYPIRLIGRKGL-IAGWGKTEAHMGHAGTNMLQVASVPIITTLD 302
            ||:||..|.:|:..:.|||||.:...|.....| |.|||.|:.:.|.....:|| |||.:|   |
Human   292 ALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVI---D 352

  Fly   303 CIRWHESKQINVEIKAEMFCAGHSDGHMDACLGDSGGPLVIKERGRFVLVGITSAGFGCGVDHQP 367
            ..|.:.......|:..:|.|||..:|.:|.|.|||||||:. :..::.:|||.|.|:|||....|
Human   353 STRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMY-QSDQWHVVGIVSWGYGCGGPSTP 416

  Fly   368 GIYHNVQKTVRWIQEV 383
            |:|..|...:.||..|
Human   417 GVYTKVSAYLNWIYNV 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13744	NP_610439.1	Tryp_SPc	141..380	CDD:214473	81/240 (34%)
CG13744	NP_610439.1	Tryp_SPc	142..383	CDD:238113	82/242 (34%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	18/83 (22%)
		Tryp_SPc	204..429	CDD:214473	81/240 (34%)
		Tryp_SPc	205..432	CDD:238113	82/242 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910