DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13744 and Corin

DIOPT Version :9

Sequence 1:	NP_610439.1	Gene:	CG13744 / 35906	FlyBaseID:	FBgn0033363	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	111/371 - (29%)
Similarity:	168/371 - (45%)	Gaps:	66/371 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GSNKWLFSCCVAETQHPHQQQHHSPSSPLANLVDYGKLKLN--LNSLPKRIML------------ 113
            |..:|:.:|.      .:..:..|||: :.:::.|..:...  |..|..|.:|
  Fly  1000 GQRQWMPACV------KNWDRAVSPSA-VCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKM 1057

  Fly   114 --RRRDD--NELLNPKP--------------ECGVPRTAQNTLQKRIIGGRPAQFAEYPWQAHI- 159
              :|:..  .|..|.|.              |||..:..::...:|||||..|....:|:.|.|
  Fly  1058 YAKRKSTLMQEFANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAIL 1122

  Fly   160 ----RIAEYQCGGVLISANMVATAAHCIQQAHLADI---TVYLGELDTQDLGHIHEPLPVEKHGV 217
                :|  :.|.|||||...|.||:||:....:.|:   |:.||........:..:.:.|:
  Fly  1123 GGPEKI--FYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVK---- 1181

  Fly   218 LQKIIHPRFNFRMTQPDRYDIALLKLAQPTSFTEHILPICLPQYPIRLI--GRKGLIAGWGKTEA 280
             ..|.||::|..:...:  ||||.:||...:|.||:||:|||...:|.:  |....:.||||.|.
  Fly  1182 -AVIPHPQYNMAIAHDN--DIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKRED 1243

  Fly   281 HMGHAGTN-MLQVASVPIITTLDCIRWHESKQINVEIKAEMFCAGHSDGHMDACLGDSGGPLVIK 344
            ....:... ::....|||||...|..|.:    |:.:...|.|||..||..|||.|||||||:..
  Fly  1244 KDPKSTYEYIVNEVQVPIITRNQCDEWLD----NLTVSEGMVCAGFDDGGKDACQGDSGGPLLCP 1304

  Fly   345 ---ERGRFVLVGITSAGFGCGVDHQPGIYHNVQKTVRWIQEVVARN 387
               |:.|:.:.||.|.|..|.....||:|.||.:.|.||||.:|::
  Fly  1305 YPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKH 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13744	NP_610439.1	Tryp_SPc	141..380	CDD:214473	88/252 (35%)
CG13744	NP_610439.1	Tryp_SPc	142..383	CDD:238113	90/254 (35%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	7/40 (18%)
		SRCR	992..1086	CDD:278931	15/92 (16%)
		Tryp_SPc	1103..1343	CDD:214473	88/252 (35%)
		Tryp_SPc	1104..1346	CDD:238113	90/254 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010