DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13744 and TMPRSS11B

DIOPT Version :9

Sequence 1:	NP_610439.1	Gene:	CG13744 / 35906	FlyBaseID:	FBgn0033363	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_872308.2	Gene:	TMPRSS11B / 132724	HGNCID:	25398	Length:	416	Species:	Homo sapiens

Alignment Length:	299	Identity:	94/299 - (31%)
Similarity:	145/299 - (48%)	Gaps:	45/299 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LKLNL---NSLPKRIMLRR--RDDNELLNPKPECGVPRTAQNTL--QKRIIGGRPAQFAEYPWQA 157
            ||.|:   |::|..|.|..  :..:|:|.... ||  |...|::  ..:|:.|:.:....:||||
Human   139 LKNNMASWNAVPASIKLMEISKAASEMLTNNC-CG--RQVANSIITGNKIVNGKSSLEGAWPWQA 200

  Fly   158 HIR-IAEYQCGGVLISANMVATAAHCI-QQAHLADITVYLGELDTQDLGHIHEPLPVEKHGVLQK 220
            .:: ...:.||..|||:..:.:||||. ::.:..|.||..|.:       :::|....|   :|.
Human   201 SMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIV-------VNKPYMTRK---VQN 255

  Fly   221 IIHPRFNFRMTQPDRY-DIALLKLAQPTSFTEHILPICLPQYPIRLIGRKG-LIAGWGKTEAHMG 283
            ||   |:...:.|..: ||||::||:..||||:|..||||:..::|..... ::.|||
Human   256 II---FHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWG------- 310

  Fly   284 HAGTNMLQVASVPIITTLDCIRWHESKQINVE------IKAEMFCAGHSDGHMDACLGDSGGPLV 342
                .:....|.|:|...|.::..::|..|..      :...|.|||...|..|||..||||||.
Human   311 ----TLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLA 371

  Fly   343 IKE-RGRFVLVGITSAGFGCGVDHQPGIYHNVQKTVRWI 380
            ..: |..:.||||.|.|.|||..::||:|..|.....||
Human   372 YPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWI 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13744	NP_610439.1	Tryp_SPc	141..380	CDD:214473	79/249 (32%)
CG13744	NP_610439.1	Tryp_SPc	142..383	CDD:238113	81/250 (32%)
TMPRSS11B	NP_872308.2	SEA	45..143	CDD:279699	2/3 (67%)
		Tryp_SPc	184..410	CDD:214473	79/249 (32%)
		Tryp_SPc	185..413	CDD:238113	81/250 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4261
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960