DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8172 and TMPRSS11D

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_004253.1	Gene:	TMPRSS11D / 9407	HGNCID:	24059	Length:	418	Species:	Homo sapiens

Alignment Length:	257	Identity:	101/257 - (39%)
Similarity:	136/257 - (52%)	Gaps:	23/257 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 CG---EVYTRS-NRIVGGHSTGFGSHPWQVALIKSGFLTRKLSCGGALISNRWVITAAHCVASTP 366
            ||   ::.|.| .||:||.....||.||||:|    .|.....|||:||:|.|::|||||..|
Human   173 CGAGPDLITLSEQRILGGTEAEEGSWPWQVSL----RLNNAHHCGGSLINNMWILTAAHCFRS-- 231

  Fly   367 NSNMKIRLGEW-DVRGQEERLNHEEYGIERKEVHPHYNPADFVNDVALIRLDRNVVYKQHIIPVC 430
            |||.:    :| ...|...........:....:|.:|..|...||:||:||:.:|.:.:.|..||
Human   232 NSNPR----DWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVC 292

  Fly   431 LPPSTTKL-TGKMATVAGWGRTRHGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLC 494
            ||.:|..: .|..|.|.|||...:...|||. |::..|.:||||.|.......|   ||....||
Human   293 LPAATQNIPPGSTAYVTGWGAQEYAGHTVPE-LRQGQVRIISNDVCNAPHSYNG---AILSGMLC 353

  Fly   495 AGYKDGGRDSCQGDSGGPLTLTMDGRKT--LIGLVSWGIGCGREHLPGVYTNIQRFVPWINK 554
            ||...||.|:||||||||| :..|.|:.  ::|:||||..||....|||||.:..::.||.:
Human   354 AGVPQGGVDACQGDSGGPL-VQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQ 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	95/240 (40%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	96/243 (40%)
TMPRSS11D	NP_004253.1	SEA	48..143	CDD:279699
		Tryp_SPc	186..412	CDD:214473	95/240 (40%)
		Tryp_SPc	187..415	CDD:238113	96/243 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4261
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960