Protein Alignment CG8172 and PRSS22

DIOPT Version :10

• Sequence 1: NP_001097235.2
• Gene: CG8172 / 35905
• FlyBaseID: FBgn0033362
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: XP_054169579.1
• Gene: PRSS22 / 64063
• HGNCID: 14368
• Length: 425
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 127/502 - (25%)
• Similarity: 191/502 - (38%)
• Gaps: 128/502 - (25%)

  Fly    70 RMIPQSCRFRGHKFECGLSISCVLGGGKPLDLCSGGMIWS----CCVDKDLDAEESPHAAPVNNT 130
            |..|:|....|....|.||..|     .|:...|...:|.    ||
Human     9 RSAPRSPVTVGVAIACSLSPPC-----SPISSSSAACLWGSTVLCC------------------- 49

  Fly   131 SDIIHLHDIYPDLSTNANKPQHHLHHHSGNGLSAAPSTSSTASSSARPAYPSSYYGTKRPTHYSG 195
                                  .....||.|.|.:...|..|...|....|
Human    50 ----------------------SCRRRSGEGTSGSSVQSRGAQVCASLEEP-------------- 78

  Fly   196 SNPYKPGSSAGGSSRPSSSSSSSLNSWEHETGGHLGSISGI--TNHLDSFFDAESQAP---LDSA 255
              ...||..||..:......|.:..:|........|...|:  ...|...:.|...:|   |::|
Human    79 --VLVPGRQAGREAAGGQGHSCAARAWPGPRKCPAGRGPGVERLESLPGHWRARGSSPPAILNAA 141

  Fly   256 GAPPPHEPLPNAQAFAVGNVLDLNAGEAADEYQSGGSGGYHDASYRPVPGCGEVYTRSNRIVGGH 320
            ..|.|                                           |.||:. .:.||:|||.
Human   142 RIPVP-------------------------------------------PACGKP-QQLNRVVGGE 162

  Fly   321 STGFGSHPWQVALIKSGFLTRKLSCGGALISNRWVITAAHCVASTPNSN--MKIRLGEWDVRGQE 383
            .:.....||.|::.|:|    ...|.|:|:::|||||||||.....|..  ..:.||.|.:....
Human   163 DSTDSEWPWIVSIQKNG----THHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPG 223

  Fly   384 ERLNHEEYGIERKEVHPHYN-PADFVNDVALIRLDRNVVYKQHIIPVCLPPSTTKL-TGKMATVA 446
            .|  .::.|:...|.||.|: ......|:||:||:|::.:.:.::|:|||.::..| ......::
Human   224 SR--SQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWIS 286

  Fly   447 GWGRTRHGQSTV-PSVLQEVDVEVISNDRCQR-WFRAAGRREAIHDVFLCAGYKDGGRDSCQGDS 509
            |||..:.|.... |..||::.|.:|.::.|.. ::|.||:.....|: |||||.:|.||:|.|||
Human   287 GWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDM-LCAGYLEGERDACLGDS 350

  Fly   510 GGPLTLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWINKVM 556
            ||||...:||...|.|::|||.||...:.||||.::.....|:.|::
Human   351 GGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	85/244 (35%)
PRSS22	XP_054169579.1	Tryp_SPc	158..396	CDD:238113	85/244 (35%)