DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8172 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	359	Identity:	110/359 - (30%)
Similarity:	165/359 - (45%)	Gaps:	49/359 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 SSSSSSLNSWEHETGGHLGSISGITNHLDSFFDAESQAPLDSAGAPPPHEPLPNAQAFAVGNVLD 277
            |...|:|...:..||          |...:.||..::|..::|.....:...|..:|..:|...|
Human   107 SKDRSTLQVLDSATG----------NWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQD 161

  Fly   278 LNAGEAADEYQ------------SGGSGGYHDASYRPVPGCGEVYTRSNRIVGGHSTGFGSHPWQ 330
            |:..|..:..|            ||.....|..:      ||: ..::.|:||.......|.|||
Human   162 LDVVEITENSQELRMRNSSGPCLSGSLVSLHCLA------CGK-SLKTPRVVGVEEASVDSWPWQ 219

  Fly   331 VALIKSGFLTRKLSCGGALISNRWVITAAHCVAS-TPNSNMKIRLGEWDVRGQEERLNHEEYGIE 394
            |::    ...::..|||:::...||:|||||... |...|.|:|.|. |..|....|...:..|
Human   220 VSI----QYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGS-DKLGSFPSLAVAKIII- 278

  Fly   395 RKEVHPHYNPADFVNDVALIRLDRNVVYKQHIIPVCLPPSTTKLTGKMAT---VAGWGRTRHGQS 456
             .|.:|.| |.|  ||:||::|...:.:...:.|:|||....:||  .||   :.|||.|:....
Human   279 -IEFNPMY-PKD--NDIALMKLQFPLTFSGTVRPICLPFFDEELT--PATPLWIIGWGFTKQNGG 337

  Fly   457 TVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAGYKDGGRDSCQGDSGGPLTLTMDGRK 521
            .:..:|.:..|:||.:.||.......|.   :.:..:|||..:||.|:|||||||||....| :.
Human   338 KMSDILLQASVQVIDSTRCNADDAYQGE---VTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QW 398

  Fly   522 TLIGLVSWGIGCGREHLPGVYTNIQRFVPWINKV 555
            .::|:||||.|||....|||||.:..::.||..|
Human   399 HVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNV 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	85/240 (35%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	86/242 (36%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	19/104 (18%)
		Tryp_SPc	204..429	CDD:214473	85/240 (35%)
		Tryp_SPc	205..432	CDD:238113	86/242 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910