Protein Alignment CG8172 and PLAT

DIOPT Version :10

• Sequence 1: NP_001097235.2
• Gene: CG8172 / 35905
• FlyBaseID: FBgn0033362
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 159/638 - (24%)
• Similarity: 233/638 - (36%)
• Gaps: 184/638 - (28%)

  Fly    15 LVVLCALICLSAPRRADA---LGYPSAQ------------QEHDMLILDALSRRSGTGYYGENSV 64
            :::||..:.:|..:...|   .|..|.|            |:|...:...| |.:...|...||.
Human    11 VLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVL-RSNRVEYCWCNSG 74

  Fly    65 MEMLSRMIPQSCR----FRGHKFECGLSIS---CVLGGGKPLDLCSGGMIWSCCVDKDLDAEESP 122
            ......:..:||.    |.|...:..|..|   |         .|..|....||   ::|...:
Human    75 RAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVC---------QCPEGFAGKCC---EIDTRAT- 126

  Fly   123 HAAPVNNTSDIIHLHDIYPDLSTNANKPQHHLHHHSGNGLSAAPSTSSTASSSAR------PAYP 181
                            .|.|                 .|:|.. .|.|||.|.|.      .|..
Human   127 ----------------CYED-----------------QGISYR-GTWSTAESGAECTNWNSSALA 157

  Fly   182 SSYYGTKRP--------THYSGSNP----------YKPGS-SAGGSSRPSSSSSSS---LNSWEH 224
            ...|..:||        .|....||          :|.|. |:...|.|:.|..:|   ..:...
Human   158 QKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSA 222

  Fly   225 ETGGHLGSISGIT----NH---LDSFFDAESQAPLDSAGAPPPHEPLPNAQAFAVGNVLDLNAGE 282
            ..|.|..:.||.:    |.   :...:.|::                |:|||..:|.
Human   223 YRGTHSLTESGASCLPWNSMILIGKVYTAQN----------------PSAQALGLGK-------- 263

  Fly   283 AADEYQSGGSGGYHDA--------------SYRPVPGCGEVYTRSN-----RIVGGHSTGFGSHP 328
              ..|.....|   ||              .|..||.|.....|..     ||.||......|||
Human   264 --HNYCRNPDG---DAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHP 323

  Fly   329 WQVALIKSGFLTRKLS------CGGALISNRWVITAAHCVAST-PNSNMKIRLGEW--DVRGQEE 384
            ||.|:    |...:.|      |||.|||:.|:::||||.... |..::.:.||..  .|.|:||
Human   324 WQAAI----FAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEE 384

  Fly   385 RLNHEEYGIERKEVHPHYNPADFVNDVALIRL----DRNVVYKQHIIPVCLPPSTTKLTG-KMAT 444
                :::.:|:..||..::...:.||:||::|    .|.......:..|||||:..:|.. ....
Human   385 ----QKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECE 445

  Fly   445 VAGWGRTRHGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAG-YKDGG-----RD 503
            ::|:|:...........|:|..|.:..:.||......   ...:.|..|||| .:.||     .|
Human   446 LSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLL---NRTVTDNMLCAGDTRSGGPQANLHD 507

  Fly   504 SCQGDSGGPLTLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWINKVM 556
            :|||||||||....|||.||:|::|||:|||::.:|||||.:..::.||...|
Human   508 ACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNM 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	87/258 (34%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494	7/42 (17%)
		Important for binding to annexin A2	42..52		0/9 (0%)
		EGF	86..117	CDD:394967	8/39 (21%)
		KR	125..209	CDD:238056	22/118 (19%)
		Kringle	215..296	CDD:395005	18/109 (17%)
		Tryp_SPc	313..559	CDD:238113	86/256 (34%)