Protein Alignment CG8172 and MST1

DIOPT Version :10

• Sequence 1: NP_001097235.2
• Gene: CG8172 / 35905
• FlyBaseID: FBgn0033362
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_001380510.1
• Gene: MST1 / 4485
• HGNCID: 7380
• Length: 737
• Species: Homo sapiens
• Alignment Length: 713
• Identity: 161/713 - (22%)
• Similarity: 237/713 - (33%)
• Gaps: 229/713 - (32%)

  Fly     1 MLPLPRHSKDTWLRLVVLCALICLSAPRRADALGYPSAQQEHDMLILDALSRRSGTGYYGENSVM 65
            :||..:||..|.||....|.|.                 |:.|.:....::  :|.||.|
Human    94 LLPWTQHSPHTRLRRSGRCDLF-----------------QKKDYVRTCIMN--NGVGYRG----- 134

  Fly    66 EMLSRMIPQSCRFRGHKFECGLSISCVLGGGKPLDLCSG-----GMIW-----------SCCVDK 114
            .|.:.:....|:...|||......:..|..|...:.|..     |..|           ||.:..
Human   135 TMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQSCGIKS 199

  Fly   115 DLDA-------EESPHAAPVNNTS--------DIIHLHDIYPDLSTNANKPQHHLHHHSGN---- 160
            ..:|       ||  :...|:.|.        |:.|.|             ||.....|..
Human   200 CREAACVWCNGEE--YRGAVDRTESGRECQRWDLQHPH-------------QHPFEPGSSTKVWT 249

  Fly   161 ----GLSAAPS--------TSSTASSSARPAYPSSYYGTKRP---------THYSGSNPYKP--- 201
                |:..|||        ..|:.||...||....:...|||         ...:|:.|..|
Human   250 TTIAGILTAPSGHGATLRIRRSSESSVTSPAAGPRHSPAKRPQLSAASAGRVRATGAQPIPPLRA 314

  Fly   202 --GSSAGGSSRPSS--------------SSSSSLNSWEHETGGHLG--------SISGI------ 236
              .|.....||.|:              :|:.:..:.......|.|        :.||:
Human   315 YLASVGTRKSRISTDLRQKNTRAKTFGRTSAGTPTAQRRPGASHCGPACARPFATRSGVVQTTCG 379

  Fly   237 ----TNHLDSFFDAESQAP--LDSAGAPP-----------PHEPLPNAQAFAVGNVLDLNAGEAA 284
                |....|...|.|..|  :.||.|.|           |...:.|.:..:.|..:.:..|..|
Human   380 PRTATTAQGSSTAARSARPARVSSASAGPLRRRTSRSSRLPPNRMHNWRRTSAGTQMGIAMGPGA 444

  Fly   285 DEYQSGGSGGYH------DA--------SYRPVPGCGEVYTRSNRIVG----GHSTGFGS----- 326
            ..:..|.    |      ||        |:.|...|      |.|.|.    |..:|..|
Human   445 TRWTQGP----HSTTVPCDAALMTSRHQSWTPQTRC------SLRSVARGWIGWISGVPSCAWLG 499

  Fly   327 -----HPWQVAL--------------IKSGFLTRKLSCGGALISNRWVITAAHCVAS--TPNSNM 370
                 ||.|.|.              ::.|    :..|||:|:..:|::||..|.:|  .|.:..
Human   500 AIRATHPGQSACGIGEAQLPVSHREELRQG----QHFCGGSLVKEQWILTARQCFSSCHMPLTGY 560

  Fly   371 KIRLGEWDVRGQEERLNHEEYGIERKEVHPHYNPADFV-----NDVALIRLDRNVVYKQHIIPVC 430
            ::.||......|     |.|..::|..|      |..|     :.:.|::|:|:|...|.:..:|
Human   561 EVWLGTLFQNPQ-----HGEPSLQRVPV------AKMVCGPSGSQLVLLKLERSVTLNQRVALIC 614

  Fly   431 LPPSTTKL-TGKMATVAGWGRTR-HGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFL 493
            |||....: .|....:||||.|: .|..||.:|..   :.||||..|.  .:..||   :.:..:
Human   615 LPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVAL---LNVISNQECN--IKHRGR---VRESEM 671

  Fly   494 CAGYKDGGRDSCQGDSGGPLTLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWINKVM 556
            |.........:|:||.||||.........|.|::.....|.|...|.|:|.:..||.||:|||
Human   672 CTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVM 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	73/275 (27%)
MST1	NP_001380510.1	PAN_AP_HGF	37..118	CDD:238532	10/40 (25%)
		KR	122..202	CDD:214527	16/86 (19%)
		KR	202..>241	CDD:412161	10/53 (19%)
		PHA03247	<234..457	CDD:223021	44/239 (18%)
		Tryp_SPc	527..733	CDD:238113	65/228 (29%)