DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8172 and Sb

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	205/758 - (27%)
Similarity:	294/758 - (38%)	Gaps:	255/758 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LVVLCALICLSAPRRA-----------DALGYP-----SAQQEHDMLILDALSRRSGTGYY---- 59
            ||.|..:.||:....|           .:||.|     |::.:.||          .:|:|
  Fly    60 LVALIVVNCLATAAAALITPPDSLESLGSLGIPSSSASSSEDDDDM----------SSGFYRIPH 114

  Fly    60 -------------GENSVMEMLSRMIPQSCRFRGHKFECGLSISCVLGGGKPLDLC-SGGMIWSC 110
                         |:|      .::.|:.|.|...:..|.....|:...||.:.:| ...|..||
  Fly   115 RLEGYPQLQQLQRGQN------FKISPKPCSFGRVEGTCMFVWECIKSEGKHVGMCVDSFMFGSC 173

  Fly   111 CV-------------------DKDLDAEESPHAAP----VNNTSDIIHLHDIYPDLSTNANKPQH 152
            |.                   .|.|.....|.|||    ::..:.|...|    ...|...:|..
  Fly   174 CTHNYTDNIVLPQTAFSYTRPTKPLTLRPRPPAAPYKPMISGMTTIERPH----GAGTLVIRPSG 234

  Fly   153 HLHHHSG--------------------NGLSAAPSTSSTASSS---------------------- 175
              .||.|                    :|.::.||:||::|||
  Fly   235 --PHHQGTLARPHPPPYQSKPTTASDLHGSASHPSSSSSSSSSSNPNSIWHTSTQQQQQQQHQQN 297

  Fly   176 ---------------------------------ARPAYPSSYYGTKRPTHYSGSNP----YKPGS 203
                                             |||:.||.  .||:|..|..:.|    ..|.:
  Fly   298 QQNHWQMTTEPSFITKPRPTGWTKPGIVNLPMPARPSKPSK--PTKKPIVYDRTPPPPPSVPPST 360

  Fly   204 SAGGSS------------------RP-----SSSSSSSLNSWEHETGGHLGSISGITN------- 238
            |...:|                  ||     :|.::||.:.|...|.....|.:..|.
  Fly   361 STSTTSTSLIWPAQTHPPQPHRPTRPQLSPGTSLAASSSSHWPSSTTSTTSSTTSTTTTTTTTRR 425

  Fly   239 --------------------HLDSFFDAESQAPLDSAGAPPPHEPLPNAQAFAVGNVLD------ 277
                                ...:...:.|.....|:..|....|:.::.:.:.|.|..
  Fly   426 TTTPTTTTRRTTTNKPTRPYQRPTTATSSSSTSTTSSKTPTTTRPISSSSSSSSGIVTSSQRPTQ 490

  Fly   278 --------LNAGEAADEYQSGGSGGYHDASYRPVPGCGEVYTRS---------------NRIVGG 319
                    ..:|...:|..        |:|.......|.|.|.|               .|||||
  Fly   491 PTHRTPVLATSGIETNEIS--------DSSIPDAGALGHVKTISAARSECGVPTLARPETRIVGG 547

  Fly   320 HSTGFGSHPWQVALIKSGFL----TRKLSCGGALISNRWVITAAHCVASTPNSNMKIRLGEWDVR 380
            .|..||..||||::.::.|.    |.:  ||||||:..|:.||.|||.....|.::||:||:|..
  Fly   548 KSAAFGRWPWQVSVRRTSFFGFSSTHR--CGGALINENWIATAGHCVDDLLISQIRIRVGEYDFS 610

  Fly   381 GQEERLNHEEYGIERKEVHPHYNPADFVNDVALIRLDRNVVYKQHIIPVCLPPSTTKLTGKMATV 445
            ..:|:|.:.|.|:.:|.|||.|:...:..|:||::|::.:.:..|:.|:|||.:.:.|.|..|||
  Fly   611 HVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLLIGMNATV 675

  Fly   446 AGWGRTRHGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAGYKDGGRDSCQGDSG 510
            .||||...| .|:|||||||.|.::|||.|:..|..|||:|.|.|:||||||:.||:||||||||
  Fly   676 TGWGRLSEG-GTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSG 739

  Fly   511 GPL-TLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWI 552
            ||| ..:.|||..|.|::||||||...:||||.|.|.:|.|||
  Fly   740 GPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWI 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	118/241 (49%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	119/242 (49%)
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	118/241 (49%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	119/242 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3236
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D75559at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25354
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	1	1.100	-	-	P	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920