DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8172 and CG1299

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	153/549 - (27%)
Similarity:	219/549 - (39%)	Gaps:	142/549 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 YYGENSVMEMLSRMI---PQSCRFRGHKFECGLSISCVLG----GGKPLDLCSGGMIWSCCVDKD 115
            |||....:....:::   ..:.|.|..::...|..||  |    .|.|:         .||.:
  Fly    43 YYGSCVALTYCPQVVNIFQTTSRDRAQRYVIALQRSC--GTRSINGDPV---------ICCTE-- 94

  Fly   116 LDAEESPHAAPVNNTSDIIHLHDIYPDLSTNANKPQHHLHHHSGNGLSAAPSTSSTASSSARPAY 180
                  |...||....    .:..:|..||... ||..........|...|.|::|.:::.....
  Fly    95 ------PRYNPVTERP----RNPFFPSESTFIG-PQPPPEVPDNPFLIPTPRTTTTTTTTTPAPI 148

  Fly   181 PSSYYG---TKRPTHYSGSNPYKPGSSAGGSSRPSSSSSSSLNSWEHE----------------- 225
            |.:...   ..|.|...|.:. |||:..  ..:..:|..:.|.|...:
  Fly   149 PDTSAAPLIEPRGTVCRGPDT-KPGNCV--EIKECASLLNELRSRSQDATFANFLRASNAVCQNK 210

  Fly   226 -------TGGHLGSISGITNHLDSFFDAESQAPLDSAGAPPPHEPLPNAQAFAVGNVLDLNAGEA 283
                   ||      .||||          ..|..|...|...:.:|...         ||..|
  Fly   211 GTQVCCPTG------QGITN----------TTPAPSQIVPKNTDEIPRRL---------LNVEE- 249

  Fly   284 ADEYQSGGSGGYHDASYRPVPGCGEVYTRSNRIVGGHSTGFGSHPWQVALI----KSGFLTRKLS 344
                                 |||.......:||||..:..|:.|| :||:    .||   ....
  Fly   250 ---------------------GCGSTVGYFKKIVGGEVSRKGAWPW-IALLGYDDPSG---SPFK 289

  Fly   345 CGGALISNRWVITAAHCVASTPNSNMK-IRLGEWDVRGQEERLNHEEYGIERKEVHPHYNPADFV 408
            |||.||:.|.|:|||||:    ..::: :||||.|:....| ..|.:..|.|...||.||..:..
  Fly   290 CGGTLITARHVLTAAHCI----RQDLQFVRLGEHDLSTDTE-TGHVDINIARYVSHPDYNRRNGR 349

  Fly   409 NDVALIRLDRNVVYKQHIIPVCLPPSTT----KLTGKMATVAGWGRTRHGQSTVPSVLQEVDVEV 469
            :|:|::.|:|||.:...|.|:|||.:..    ...|.|..|||||:|..|..:. .||.|:.:.:
  Fly   350 SDMAILYLERNVEFTSKIAPICLPHTANLRQKSYVGYMPFVAGWGKTMEGGESA-QVLNELQIPI 413

  Fly   470 ISNDRC-------QRWFRAAGRREAIHDVFLCAGYKDGGRDSCQGDSGGPLTL--TMDG--RKTL 523
            ..|..|       :|:|.|....:|:    ||||...||:|:|||||||||.|  ...|  |..|
  Fly   414 YDNKVCVQSYAKEKRYFSADQFDKAV----LCAGVLSGGKDTCQGDSGGPLMLPEPYQGQLRFYL 474

  Fly   524 IGLVSWGIGCGREHLPGVYTNIQRFVPWI 552
            ||:||:||||.|.::||||::.|.|:.||
  Fly   475 IGVVSYGIGCARPNVPGVYSSTQYFMDWI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	100/256 (39%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	102/257 (40%)
CG1299	NP_647862.1	CLIP	37..93	CDD:197829	12/60 (20%)
		CLIP	164..216	CDD:288855	7/54 (13%)
		Tryp_SPc	260..503	CDD:214473	100/256 (39%)
		Tryp_SPc	261..503	CDD:238113	100/255 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
	3	3.010