DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8172 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	273	Identity:	107/273 - (39%)
Similarity:	143/273 - (52%)	Gaps:	22/273 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 GSGGYHDASYRPVPGCGEVYTRSNRIVGGHSTGFGSHPWQVALIKSGFLTRKLSCGGALISNRWV 355
            |.....|.|......|| :...|:|||||..:..|..|||.:|...|    :..||||||::|||
  Rat   553 GQADCRDGSDEEHCDCG-LQGPSSRIVGGAMSSEGEWPWQASLQIRG----RHICGGALIADRWV 612

  Fly   356 ITAAHCVASTPNSNMKIRLGEWDVRGQEERLNHE-----EYGIERKEVHPHYNPADFVNDVALIR 415
            ||||||......::.::    |.|...:.|.|..     .:.:.|..:||::.......||||::
  Rat   613 ITAAHCFQEDSMASPRL----WTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQ 673

  Fly   416 LDRNVVYKQHIIPVCLPPSTTKL-TGKMATVAGWGRTRHGQSTVPSVLQEVDVEVISNDRCQRWF 479
            ||..|||...:.|||||..:... .|:...:.|||..|.| ....|.||:|||::|..|.|...:
  Rat   674 LDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREG-GPGSSTLQKVDVQLIPQDLCNEAY 737

  Fly   480 RAAGRREAIHDVFLCAGYKDGGRDSCQGDSGGPLTL-TMDGRKTLIGLVSWGIGCGREHLPGVYT 543
                 |..:....|||||:.|.:|:|||||||||.. ...||..|.||||||:||||.:..||||
  Rat   738 -----RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYT 797

  Fly   544 NIQRFVPWINKVM 556
            .:.|.|.||.:|:
  Rat   798 RVTRVVNWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	98/243 (40%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	99/245 (40%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486	3/12 (25%)
		Tryp_SPc	576..806	CDD:214473	98/243 (40%)
		Tryp_SPc	577..809	CDD:238113	99/245 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810