DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8172 and Tmprss13

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001121000.1	Gene:	Tmprss13 / 300682	RGDID:	1310872	Length:	539	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	154/558 - (27%)
Similarity:	213/558 - (38%)	Gaps:	152/558 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 AEESPHAAPVNNTSDIIHLHDIYPDLS-TNANKPQHHLHHHS--------GNGLSAAPSTSSTA- 172
            |..||.|:|...:..........|..| ..|:.||......|        .:...|.||.||:.
  Rat    12 ARPSPQASPARASPQASPARTPPPQASPARASPPQASPARASPARASPVRASPARAPPSRSSSGR 76

  Fly   173 SSSARPA----YPSSYY-------GTKRPTHYSGSNPYKPGSSAGGSSRPSSSSSSSLNSWEHET 226
            |||||.|    .|:..|       ||......:.|.|      |..::|.|...|....||: ||
  Rat    77 SSSARSASTTSSPTRVYLVRAIPVGTVIRASPARSAP------ATRATRESPGLSFPKFSWQ-ET 134

  Fly   227 -------GGHLGSISGITNHLDSFF------DAESQAPLDSAGAPPPHEPLPNAQAFAVGNVLDL 278
                   |..|..||.:.:.:..|:      ..:.:.||:|.   |.|       |.....|:|.
  Rat   135 QRQLPLIGCVLLLISLVISLILLFYFWRGHTGIKYKEPLESC---PKH-------AVRCDGVVDC 189

  Fly   279 NAGEAADE--------------YQSGGSGGY---------------------HDASYRPV----- 303
            ..  .:||              ..||.||.:                     .|::||..
  Rat   190 KM--KSDELGCVRFDWDKSLLKVYSGSSGEWLPVCSSSWNDTDSERTCQQLGFDSAYRTTEVAHR 252

  Fly   304 ------------------------PG----------CGEVYTRSNRIVGGHSTGFGSHPWQVALI 334
                                    |.          || :...:.|||||..|.....||||:|
  Rat   253 DVTSSFLLSEYNSTIQESLTRSECPSRRYVSLQCAHCG-LRAMTGRIVGGALTSESKWPWQVSL- 315

  Fly   335 KSGFLTRKLSCGGALISNRWVITAAHCVASTPNSNMKIRLGEWDVRGQEERLNH--EEYGIERKE 397
              .|.|..: |||.||..:||:|||||...|   ..||..| |.|......|:.  |...|.:..
  Rat   316 --HFGTTHI-CGGTLIDAQWVLTAAHCFFVT---REKILEG-WKVYAGTSNLHQLPEAASISQII 373

  Fly   398 VHPHYNPADFVNDVALIRLDRNVVYKQHIIPVCLP-PSTTKLTGKMATVAGWGRTRHGQSTVPSV 461
            ::.:|.......|:||:||.:.:....||.|.||| ...|....:...:.|:|:|:.........
  Rat   374 INGNYTDEQDDYDIALVRLSKPLTLSAHIHPACLPLHGQTFGLNETCWITGFGKTKETDEKTSPF 438

  Fly   462 LQEVDVEVISNDRCQRWFRAAGRREAIHDVFL-----CAGYKDGGRDSCQGDSGGPLTLTMDGRK 521
            |:||.|.:|...:|..:.        ::|.:|     |||...||||||||||||||....:.|.
  Rat   439 LREVQVNLIDFKKCNDYL--------VYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRW 495

  Fly   522 TLIGLVSWGIGCGREHLPGVYTNIQRFVPWINKVMAND 559
            .|.|:.|||.|||:::.|||||.:...:|||.:.|.::
  Rat   496 YLAGVTSWGTGCGQKNKPGVYTKVTEVLPWIYRKMESE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	90/244 (37%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	91/246 (37%)
Tmprss13	NP_001121000.1	WWbp	<1..69	CDD:304964	12/56 (21%)
		SRCR_2	203..292	CDD:292133	10/89 (11%)
		SRCR	216..288	CDD:278931	5/71 (7%)
		Tryp_SPc	297..526	CDD:214473	90/244 (37%)
		Tryp_SPc	298..526	CDD:238113	89/243 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910