DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8172 and Prss50

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_666339.2	Gene:	Prss50 / 235631	MGIID:	2447303	Length:	439	Species:	Mus musculus

Alignment Length:	456	Identity:	101/456 - (22%)
Similarity:	164/456 - (35%)	Gaps:	154/456 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 KPQHHLH-------HHSGNGLSAAPSTSSTASSSARPAYPSSYYGTKRPTHYSGSNPYKPGSSAG 206
            :|..|.|       .....|..||.::..|.|::.                     |..||.|.|
Mouse    54 RPPRHAHPRPPLTRWRPSTGYLAAGASPGTLSTTV---------------------PTGPGVSCG 97

  Fly   207 GSSR---PSSSSSSSLNSWEHETGGHLGSISGITNHLDSFFDAESQAPLDSAGAPPPHEPLPNAQ 268
              ||   ||........:..::|                     :.||             ||:|
Mouse    98 --SRGICPSGRLRLPRQAQTNQT---------------------TTAP-------------PNSQ 126

  Fly   269 AFA----VG--NVLDLNAGEAADEYQSGGSGGYHDASYRPVPGCG------------EVYTRSNR 315
            ..|    ||  .::|.........:.|.            :|.||            |..||
Mouse   127 TMAPLKTVGTLGMMDTTGSVLKTVHSSN------------LPFCGSSHEPDPTLRDPEAMTR--- 176

  Fly   316 IVGGHSTGFGSHPWQVALIKSGFLTRKLSCGGALISNRWVITAAHCVASTPNSNMKIRLGE-WDV 379
                      ..||.|::..:|    ...|.|.||:::||:|.|||: |..:.|..:|.|. |
Mouse   177 ----------RWPWMVSVQANG----SHICAGILIASQWVLTVAHCL-SQNHVNYIVRAGSPW-- 224

  Fly   380 RGQEERLNH-----EEYGIERKEVHPHYNPADF------VNDVALIRLDRNVVYKQHIIPVCLPP 433
                  :|.     .:..:.|..::..|.|..:      .:|:.|::|...:.|.:::.|:|||.
Mouse   225 ------INQTAGTSSDVPVHRVIINHGYQPRRYWSWVGRAHDIGLLKLKWGLKYSKYVWPICLPG 283

  Fly   434 STTKL-TGKMATVAGWGRTRHG------QSTVPSVLQEVDVEVISNDRCQRWFRAAGRREA---- 487
            ....: ...:.||.|||..|..      ||     |||.:|.::::.:|..::....|..:
Mouse   284 LDYVVEDSSLCTVTGWGYPRANGIWPQFQS-----LQEKEVSILNSKKCDHFYHKFSRISSLVRI 343

  Fly   488 IHDVFLCAGYKDGGRDS-CQGDSGGPLTLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPW 551
            |:...:||  .|..|:. |...:|.||..:.||...|:|::|||.||.:...|.::..:..:.||
Mouse   344 INPQMICA--SDNNREEFCYEITGEPLVCSSDGTWYLVGMMSWGPGCKKSEAPPIFLQVSYYRPW 406

  Fly   552 I 552
            |
Mouse   407 I 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	65/260 (25%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	67/261 (26%)
Prss50	NP_666339.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..130		23/132 (17%)
		Tryp_SPc	177..407	CDD:214473	65/249 (26%)
		Tryp_SPc	177..407	CDD:238113	65/249 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910