Protein Alignment CG8172 and F11

DIOPT Version :10

• Sequence 1: NP_001097235.2
• Gene: CG8172 / 35905
• FlyBaseID: FBgn0033362
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: XP_005262878.1
• Gene: F11 / 2160
• HGNCID: 3529
• Length: 626
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 153/572 - (26%)
• Similarity: 238/572 - (41%)
• Gaps: 111/572 - (19%)

  Fly    61 ENSVMEMLSRMIPQSCRFRGHKF-ECGLSISCVLGGGKPL--DLCSGGMIWSCCVDKDLDAEESP 122
            ::||.|.|.| :.::....|:.| :|...||..   .|.:  ||...|:.::..|.|  .|:|..
Human    79 KDSVTETLPR-VNRTAAISGYSFKQCSHQISAC---NKDIYVDLDMKGINYNSSVAK--SAQECQ 137

  Fly   123 HAAPVNNTSDIIHLHDIYPDLSTNANKPQHHLHH-------HSGNG----------LSAAPSTSS 170
                 ...:|.:|.|     ..|.|.:....|.|       |:..|          :.:..|..|
Human   138 -----ERCTDDVHCH-----FFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKS 192

  Fly   171 TASSS---ARPAYPSSYYG-------------------TKRP-----THYSGSNP---------Y 199
            .|.|:   .|..:|::.:.                   |..|     |.:|...|         .
Human   193 CALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLL 257

  Fly   200 KPGSSAGGSSRPSSS---SSSSLNSWEHETGGHLGSISGITNHLDSFFDAESQAPLDSAGAPPPH 261
            |...|...|:|...|   |..||.|..|       ||. :..|...:.|.:.........|...|
Human   258 KTSESGLPSTRIKKSKALSGFSLQSCRH-------SIP-VFCHSSFYHDTDFLGEELDIVAAKSH 314

  Fly   262 EP----LPNA---QAF----AVGNVLDLNAGEAADEYQSGGS--------GGYHDASYRPVPGCG 307
            |.    ..||   |.|    |..:..:.|.|:...:..|.||        ||....:.|......
Human   315 EACQKLCTNAVRCQFFTYTPAQASCNEGNRGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDN 379

  Fly   308 EVYTR-SNRIVGGHSTGFGSHPWQVALIKSGFLTRKLSCGGALISNRWVITAAHCVASTPNSNMK 371
            |..|: ..|||||.::..|..||||.|..:....|.| |||::|.|:|::|||||.....:..:
Human   380 ECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHL-CGGSIIGNQWILTAAHCFYGVESPKI- 442

  Fly   372 IRLGEWDVRGQEERLNHEEYGIERKEVHPHYNPADFVNDVALIRLDRNVVYKQHIIPVCLPPSTT 436
            :|:....:...|.:.:...:|::...:|..|..|:...|:||::|:..|.|.....|:|||....
Human   443 LRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 507

  Fly   437 K-LTGKMATVAGWGRTRHGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAGYKDG 500
            : :......|.||| .|..:..:.:.||:..:.:::|:.||:.:|.    ..|....:||||::|
Human   508 RNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKRYRG----HKITHKMICAGYREG 567

  Fly   501 GRDSCQGDSGGPLTLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWI 552
            |:|:|:|||||||:...:....|:|:.|||.||.:...||||||:..:|.||
Human   568 GKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	82/238 (34%)
F11	XP_005262878.1	APPLE	20..103	CDD:128519	7/24 (29%)
		APPLE	110..193	CDD:128519	18/97 (19%)
		APPLE	200..283	CDD:128519	15/82 (18%)
		APPLE	291..375	CDD:128519	18/83 (22%)
		Tryp_SPc	389..619	CDD:238113	80/236 (34%)