Protein Alignment CG8172 and Plat

DIOPT Version :10

• Sequence 1: NP_001097235.2
• Gene: CG8172 / 35905
• FlyBaseID: FBgn0033362
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_032898.2
• Gene: Plat / 18791
• MGIID: 97610
• Length: 559
• Species: Mus musculus
• Alignment Length: 1775
• Identity: 317/1775 - (17%)
• Similarity: 562/1775 - (31%)
• Gaps: 597/1775 - (33%)

  Fly   848 GKATAQLIQSIKGEAESQHDSN--------MQRKLLEAAKQLADATARMVEAARLCAGNPHDSGH 904
            |:...:|||::...:.||..|.        .|.|....:..|:|   |....:.||:......|.
Mouse   328 GEVLPKLIQTVTAGSISQEKSTDLEPNGPVEQEKNHSNSSTLSD---RRGSNSSLCSIEEEHRGV 389

  Fly   905 QEMLRTAAEELRVITTSTANTPAIKRQLIGRLEQCARQAASSATQCITAAQNSLIHSNDVQTKEI 969
            .:|       ::.|..||                                ::::...|:|..:..
Mouse   390 YDM-------VQAILLST--------------------------------RDNVNFVNEVFHQAF 415

  Fly   970 LLQDCQA-------------VADQIPRLVAGVKGTHARPDDPNAQL------------------- 1002
            ||..|:|             :..:.|..:|..:.|:...|....||
Mouse   416 LLPSCEASATRKVIKVYRKWILQEKPAFMAEPETTNQEEDTEEEQLVTETDNAHIQALETHGHKR 480

  Fly  1003 -----------------CLIDAAEMFLEPGAQMAGSARELQPTVMDQAAGQQLGRSSVNLTHAIH 1050
                             ||.:...:.::.|.|.|     ||..:.:.|        :|.|.....
Mouse   481 SSSWGRTYSFSSAISRGCLTEELNLEVKAGIQSA-----LQVFLTNSA--------NVFLLEPCQ 532

  Fly  1051 DLRLAAHRAREACGGNELDAALEAVRNLRSVLSDTRRAAQEGSLRPLPGETADSCFKQLAAASNA 1115
            |:........|.|               |:|||..|....|.::.   .:|.:...:.|...:.|
Mouse   533 DVPKLLENQLEVC---------------RAVLSVYRHIIMEQNMN---RQTWEQLLQVLLRITEA 579

  Fly  1116 VDVSMHQLMSAAQQGNRTYAGVAGRDTALALGDYTKSVRGVLVTTKNPAVVDCADEVIVDSLRVI 1180
            |       |...|:..:       :||      :..|:..:|..|...|.|. |:..:..|..:.
Mouse   580 V-------MKRPQENQK-------KDT------FAHSLASILFKTIFVAWVR-ANLTVFISRELW 623

  Fly  1181 EEAQRTLQNLDNQEALL---------IAIKRTKHSLGRTIDCLPGVKDINEAFETVTDLRSIL-D 1235
            :|....|.:|.:.|.|:         :.....:|..|..:..|| :..::|..|.....|.:: |
Mouse   624 DELLAVLSSLSHWEELVFEWASIMDSLTAVLARHVYGLDLHNLP-LDKLSEQKEKKQRGRGVMAD 687

  Fly  1236 TGEYPPSDRPYGQLQNELKSAADQLNVAGGQVAQSYDSSIKLAGTSQEFCHAYKELLTVTLEMAG 1300
            :.:...:.|.:..   ..|::.||:   |.|....:.|:                  |.|    |
Mouse   688 SHKVSEAGRSFSL---SWKNSGDQV---GAQEPMRFRSA------------------TTT----G 724

  Fly  1301 QTAEDRAREEIVNSLRGVSNQSISLLGTARYVAGDPDRPNAKNELSSAARLVTESINRLVDVCTQ 1365
            ..|.::||..:                          |..||.         ::||:..|.:| :
Mouse   725 TPAVEKARNNV--------------------------RQKAKR---------SQSISNCVHLC-E 753

  Fly  1366 AAPGQKECDGAIRSIESLRPLLESPQESLTDQGYFDCLDTVLEKSRTLGEGMTGIANNAKNSKHV 1430
            |.|..|.....:.::.|..|.:.  ..|.......|..:..|.:.. :|:|.:.:..::..|...
Mouse   754 ALPATKSVPMLLHTVSSFLPGIS--HNSHCSHRLSDVEECQLSECE-MGDGDSPLPRSSSTSDIT 815

  Fly  1431 EFGHSVNSVSESIRGLIESAAQAAYLVGVSNPTSVGGR--------------PGIVD-PAQYARA 1480
            :      .::::..|..:..:.......||..:|.|.|              |..:| ||:.|.|
Mouse   816 Q------QINDTFTGQRKDESMDLVRSSVSESSSAGTRESDAPVILIERSNSPADLDYPAEGAPA 874

  Fly  1481 --AQAIRQSCDVLRGQASSQPQVLSAATV--IAKHTSALCNACRNASSTTTNPVAKRHFVQAAKE 1541
              ...:|:..:.:..:.|:  ..|:.|.|  ::.||..     ....|.:|..|:....|.|  :
Mouse   875 FLKMKLREKSESVSSETSN--GYLNEAEVGLLSWHTLE-----EEPDSPSTQDVSMSMSVTA--D 930

  Fly  1542 VANSTAALVREIKAL--DQDYSPAS-----RQRCAAATEPLLEAVSSLCHFASSPEF----ISIP 1595
            ..:..:.|:...:||  ...:.|.|     ...|....:.|.:|::...|..|| ||    |||.
Mouse   931 TVSQRSLLLSHTEALAGSPHFPPVSPALLVPHGCCEGPQLLEDAMNMPQHLDSS-EFLADDISII 994

  Fly  1596 ARISTEGRKAQEPILTAGR--GILDGAVDMVRTAKVLA-LTPTDPPVWQQLATHSRNVS------ 1651
            |..|..|..|....:...|  ||| |.|:.:|.|::.| :......:|.:||....|:.
Mouse   995 AGGSLTGWHADSAFVLWRRILGIL-GDVNSIRCARIHAKVFSYLYELWHKLAKIRDNLGIRVDSD 1058

  Fly  1652 ---------ESIKQLASSI-------REKAPGQMQ-----CDQVL-------------------- 1675
                     ..::.|||.:       .|...|::|     |:.:.
Mouse  1059 TAMVKPLFIPPLRMLASWLFKATMLPSEFKAGKLQAYKLICEMMTKHQDVLPNSDFLVHLYHVMH 1123

  Fly  1676 --------EVLKDCSRELNSAALAVGVDGLPQRKDSNLQGFT---NQSLNAASELI--DRLEPVK 1727
                    :||....|..:.....:|           |.|||   ...:.||:.::  |..|..:
Mouse  1124 KGFTSDDQDVLNTMIRWCSPRFFFLG-----------LPGFTMLVGDFITAAARILNTDSFEAPR 1177

  Fly  1728 SSAKKNAESLGHAVNQIAKHIVPLTNGVIGACSQLVHSGQQ-------TVLINQVKS-------- 1777
            ..|:....||....|...:  :|....|.|:...||  |::       .:|:...:|
Mouse  1178 VEAQAVLGSLVCFPNLYQQ--IPSLQSVPGSEDILV--GKEDMKDYLVNILLKTARSETCEGARC 1238

  Fly  1778 VVEC------CAQLVQTAKQAGGNPRAAHFHPELDEAVESTREAIQELNATVERLSTENGVVTGL 1836
            |..|      |.:|.||                  |.....::||..|..|   |...|.||..:
Mouse  1239 VAICGLGLWVCEELRQT------------------ETHHQVKDAINVLGVT---LKFGNKVVANV 1282

  Fly  1837 --------------MEQISRSMSR----ISDKRQSFLGASLNDTYVDYQTRMVQS---------- 1873
                          ::::..|:.:    |.....:||..|...:.|:...:::.|
Mouse  1283 ACDIFQLLISHWQHLQRLEPSLPKRIIEIFVATVAFLLPSAEHSTVEADKKLMVSLLLCLLDWCM 1347

  Fly  1874 AKEIARYANEINAKAAIDPS-----------KLAQLCVEMTHHYTQLAQDSIGASALTTSPDVAI 1927
            :..::.....|......||:           ::...||..::.:||.:...:..:.|:|..:..:
Mouse  1348 SVPLSILLEPITMPVLDDPTSQKAPLLDYIYRVLHTCVSGSNLHTQQSHYLLSLADLSTDYEPFL 1412

  Fly  1928 -----------RIRNTVQDLGRSVNV----------LIQSTTG---------------------- 1949
                       .|.|.:.|.|..:.|          ||..|..
Mouse  1413 MLGNVKSFEPPAIHNAMGDFGNLLTVAEEKKRRSMELIPLTARMVMTHLVNHLGHHPLSGGPALL 1477

  Fly  1950 ---IRKDDSSGLVEISRGARDVSEKV---------AQVLAALQAGS-RGTQACINA-----SSTV 1996
               |.::..:..||.|..:.:|.:..         :.:::.||..| ....|.::|     ||.|
Mouse  1478 NSLISENHDNPYVESSELSSEVFKSPNLQLFVFNDSTLISYLQIPSDNSNTAPLSANPRDHSSEV 1542

  Fly  1997 SAIISDL------DTTIMFATA-GTLQSSDEDGKFSDHREHILKTAKALVEDTKILVAGAAGTQD 2054
            ..||.|:      |:.::|.|. ||..:|      ||.||.....|..|.:.:.:..:..:...|
Mouse  1543 RIIIRDISGKYSWDSGVLFRTLDGTGVTS------SDSREQSSHEAARLEKRSSVRFSKCSSELD 1601

  Fly  2055 QLAAAAQNAVTTILQLADAVKHGA------ASLGSGQPDSQVMVIN------------------- 2094
                 .::.|..:.||.:.:.|.:      ..|...||.|..|.:|
Mouse  1602 -----VEDGVDVLDQLLEDLGHSSPECLPEPQLRLTQPPSPPMGMNLEIEGLIMEAVHRQSKQEE 1661

  Fly  2095 ------AVKDVAAALGELINATKLASGKP-------INDPAMN--DLKDSAKVMVMNVTSLLKTV 2144
                  .::|.:.........|......|       :||..||  |.:.|..::..| :.||:.:
Mouse  1662 EELMRRQIEDPSVRAERQKEPTHQEPKSPFYLCRLLLNDLGMNSWDRRKSFHLLKKN-SKLLREL 1725

  Fly  2145 KAVEDEHTRGTRAMEATVDAISQELRSMQFAPEMMRSSMQQLSRPEDLIS-------VTKHV--- 2199
            |.::....|.|..:........||.:      ..:.|:.|.....||.:|       :..|.
Mouse  1726 KNLDSRQCRETHKIAVFYIGEGQEDK------YSILSNTQGSQVYEDFVSGLGWEVNLATHCGFM 1784

  Fly  2200 --------TAATAKAVAAGASNLQADIAAAANLGRKTISDMLSVCKS----------VAWSCAET 2246
                    |.:||...|  .||::.....:..:  .:.||. |:.|.          :.|| ..|
Mouse  1785 GGLQRNGSTGSTAPYYA--TSNVEVIFHVSTRM--PSDSDD-SITKKLRHLGNDEVHIVWS-EHT 1843

  Fly  2247 QDLRQRTL--DAGSAVAIAY 2264
            :|.|:..:  |.|..:.|.|
Mouse  1844 RDYRRGIIPTDFGDVLVIIY 1863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113
Plat	NP_032898.2	FN1	38..80	CDD:214494
		Important for binding to annexin A2. /evidence=ECO:0000250	39..49
		EGF	83..115	CDD:394967
		Kringle	124..205	CDD:395005
		KR	210..295	CDD:238056
		Tryp_SPc	311..556	CDD:238113	49/297 (16%)