DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8172 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	299	Identity:	110/299 - (36%)
Similarity:	146/299 - (48%)	Gaps:	46/299 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 QSGGSGGYHDASYRPVPGCGEVYTRSNRIVGGHSTGFGSHPWQVALIKSGFLTRKLSCGGALISN 352
            |..|.....|.|......|| :...|:|||||..:..|..|||.:|...|    :..||||||::
Human   541 QCDGRPDCRDGSDEEHCDCG-LQGPSSRIVGGAVSSEGEWPWQASLQVRG----RHICGGALIAD 600

  Fly   353 RWVITAAHC-----VASTPNSNMKIRLGE-WDVRGQEERLNHE-EYGIERKEVHPHYNPADFVND 410
            |||||||||     :|||  ....:.||: |    |..|...| .:.:.|..:||::.......|
Human   601 RWVITAAHCFQEDSMAST--VLWTVFLGKVW----QNSRWPGEVSFKVSRLLLHPYHEEDSHDYD 659

  Fly   411 VALIRLDRNVVYKQHIIPVCLPPSTTKL-TGKMATVAGWGRTRHGQ------------------- 455
            |||::||..||....:.|||||..:... .|....:.|||..|.|.
Human   660 VALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSET 724

  Fly   456 --STVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAGYKDGGRDSCQGDSGGPLTL-TM 517
              ..:.:.||:|||::|..|.|...:     |..:....|||||:.|.:|:|||||||||.. .:
Human   725 CCCPISNALQKVDVQLIPQDLCSEVY-----RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKAL 784

  Fly   518 DGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWINKVM 556
            .||..|.||||||:||||.:..||||.|...:.||.:|:
Human   785 SGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVV 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	100/266 (38%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	101/268 (38%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486	4/15 (27%)
		Tryp_SPc	568..822	CDD:238113	101/268 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810