DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8172 and Tmprss3

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001157248.1	Gene:	Tmprss3 / 140765	MGIID:	2155445	Length:	475	Species:	Mus musculus

Alignment Length:	365	Identity:	114/365 - (31%)
Similarity:	154/365 - (42%)	Gaps:	78/365 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 PSSSSSSSL--NSWEHETGGHLGSISGITNHLDSFFDAESQAPLDSAGAPPPHEPLPNAQAFAVG 273
            ||..||..|  ::.|.:..|...||    |||           |........|..:...:....|
Mouse   170 PSYVSSDHLRVDALEEQFQGDFVSI----NHL-----------LSDDKVTALHHSVYMREGCTSG 219

  Fly   274 NVLDLNAGEAADEYQSGGSGGYHDASYRPVPGCGEVYTRSNRIVGGHSTGFGSHPWQVALIKSGF 338
            :|:.|...                       .||.....|.|||||:.:.....||||:|...|:
Mouse   220 HVVTLKCS-----------------------ACGTRTGYSPRIVGGNMSSLTQWPWQVSLQFQGY 261

  Fly   339 LTRKLSCGGALISNRWVITAAHCVAST--PNSNMKIRLGEWDVR-GQEERLNH--EEYGIERKEV 398
            ..    |||::|:..|::||||||...  |.|        |.|: |....::.  ..:.:|:...
Mouse   262 HL----CGGSIITPLWIVTAAHCVYDLYHPKS--------WTVQVGLVSLMDSPVPSHLVEKIIY 314

  Fly   399 HPHYNPADFVNDVALIRLDRNVVYKQHIIPVCLPPSTTKL-TGKMATVAGWGRTRHGQSTVPSVL 462
            |..|.|....||:||::|...:.:.:.|.|:|||.|.... .||:...:|||.|..|....| ||
Mouse   315 HSKYKPKRLGNDIALMKLSEPLTFDETIQPICLPNSEENFPDGKLCWTSGWGATEDGGDASP-VL 378

  Fly   463 QEVDVEVISNDRCQRWFRAAGRREAIHDVF--------LCAGYKDGGRDSCQGDSGGPLTLTMDG 519
            ....|.:|||..|..           .||:        |||||..||.|||||||||||......
Mouse   379 NHAAVPLISNKICNH-----------RDVYGGIISPSMLCAGYLKGGVDSCQGDSGGPLVCQERR 432

  Fly   520 RKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWINKVMAND 559
            ...|:|..|:||||...:.|||||.|..|:.||::.:..|
Mouse   433 LWKLVGATSFGIGCAEVNKPGVYTRITSFLDWIHEQLERD 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	91/250 (36%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	92/252 (37%)
Tmprss3	NP_001157248.1	LDLa	96..129	CDD:238060
		SRCR_2	134..233	CDD:292133	19/100 (19%)
		Tryp_SPc	238..465	CDD:214473	91/250 (36%)
		Tryp_SPc	239..468	CDD:238113	92/252 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810