DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8172 and TMPRSS11B

DIOPT Version :9

Sequence 1:	NP_001097235.2	Gene:	CG8172 / 35905	FlyBaseID:	FBgn0033362	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_872308.2	Gene:	TMPRSS11B / 132724	HGNCID:	25398	Length:	416	Species:	Homo sapiens

Alignment Length:	292	Identity:	96/292 - (32%)
Similarity:	140/292 - (47%)	Gaps:	62/292 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 ASYRPVPG-------------------CGEVYTRS----NRIVGGHSTGFGSHPWQVALIKSGFL 339
            ||:..||.                   ||.....|    |:||.|.|:..|:.|||.::...|
Human   144 ASWNAVPASIKLMEISKAASEMLTNNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKG-- 206

  Fly   340 TRKLSCGGALISNRWVITAAHCVASTPNSNMKIRLGEWDVRGQEERLNHEEYGI-------ERKE 397
              :..||.:|||:||:::||||.|...||.      :|.|          .:||       .||.
Human   207 --RHYCGASLISSRWLLSAAHCFAKKNNSK------DWTV----------NFGIVVNKPYMTRKV 253

  Fly   398 ----VHPHYNPADFVNDVALIRLDRNVVYKQHIIPVCLPPSTTKLT-GKMATVAGWGRTRHGQST 457
                .|.:|:.....:|:||::|...|.:.::|..:|||.:..||: .....|.||| |.:...:
Human   254 QNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWG-TLYMNGS 317

  Fly   458 VPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAGYKDGGRDSCQGDSGGPLTLTMDGRKT 522
            .|.:|||..:::|.|..|...:..:|   .:.|..||||:..|..|:||.||||||... |.|..
Human   318 FPVILQEDFLKIIDNKICNASYAYSG---FVTDTMLCAGFMSGEADACQNDSGGPLAYP-DSRNI 378

  Fly   523 --LIGLVSWGIGCGREHLPGVYTNIQRFVPWI 552
              |:|:||||.|||:::.|||||.:..:..||
Human   379 WHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWI 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8172	NP_001097235.2	Tryp_SPc	315..552	CDD:214473	86/250 (34%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	88/251 (35%)
TMPRSS11B	NP_872308.2	SEA	45..143	CDD:279699
		Tryp_SPc	184..410	CDD:214473	86/250 (34%)
		Tryp_SPc	185..413	CDD:238113	88/251 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4261
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960