DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Np and tmprss4a

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_005157547.1	Gene:	tmprss4a / 777630	ZFINID:	ZDB-GENE-061103-631	Length:	458	Species:	Danio rerio

Alignment Length:	471	Identity:	130/471 - (27%)
Similarity:	193/471 - (40%)	Gaps:	81/471 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 PPSNWLPLTTESSETADKTSASTAP----PSATD--KVVISV----------ATSVSEVETHGPG 676
            |..|..||.....|.|.:|...|||    |...:  |::|:|          |.:...::.....
Zfish     8 PEENTTPLNPPKPEPAKRTKLMTAPKTQKPKGPNKKKIIITVLMVVVVLAILAVAAFLIKQLIDS 72

  Fly   677 KPQKTTKPPK---------PSSTAKPTTTTTAAATTIVKTTEAPASSIELASSTSSYTDLG-SDL 731
            |....||..|         ..:........:|..|.....|..|   :.|.|:.:....|. ||.
Zfish    73 KYFFCTKSWKFIPLEKVCDGKNDCSEAEDESACVTMFKPNTTFP---LRLYSANNVLQVLSPSDN 134

  Fly   732 AASSSSSTTTTTSSPTTAAETTDYS----------GEEPNTTTIEATGSTTVAPANALEGVDYKE 786
            ...|..|.:.|.....||.:...||          |..|:...|......|..|......|..::
Zfish   135 TWKSVCSESFTQQHAETACQLLGYSVSPVFSSIAVGPLPSDLKISFCMVGTTKPQTFQSAVSDRK 199

  Fly   787 VCGRRMF-------------PEPRIVGGANAAFGRWPWQISLRQWRTSTYLHKCGAALLNENWAI 838
            ||.....             .:.|||||.:|....||||:||:.    :..|.||.:|:..||.:
Zfish   200 VCSTGTVISLSCSADCGLSRNQDRIVGGKDADIANWPWQVSLQY----SGQHTCGGSLVTPNWVV 260

  Fly   839 TAAHCVDNVPPSDLLLRLGEYDLAE-----EEEPYGYQERRVQIVASHPQFDPRTFEYDLALLRF 898
            |||||.:    .|....|..:.:..     ...|..|    |:.:..:..:.|...::|:.:::.
Zfish   261 TAAHCFN----GDGRKALSRWTVVSGITYLSSTPSSY----VKEIIVNSNYKPAESDFDITMIKL 317

  Fly   899 YEPVIFQPNIIPVCVPDNDENFIGQTAF-VTGWGRLYE-DGPLPSVLQEVAVPVINNTICES--M 959
            ..|:....:..|||:|..:....|.... |||||.:.| .|.|.|:||:..:.||::..|.|  :
Zfish   318 QSPITLSESRRPVCLPPQNLGLKGGDGLVVTGWGHMAEKGGSLSSMLQKAQIQVIDSAQCSSPTV 382

  Fly   960 YRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQPGV 1024
            |.|:     |....||||...||.|:|:||||||:|...:   |:.|.||:|||:|||....|||
Zfish   383 YGSS-----ITPRMICAGVMAGGVDACQGDSGGPLVHLAD---RWVLVGVVSWGVGCARPGFPGV 439

  Fly  1025 YTRISEFRDWINQILQ 1040
            ||.:.:..||.:.::|
Zfish   440 YTNVDQMLDWAHSVMQ 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	85/246 (35%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	85/248 (34%)
tmprss4a	XP_005157547.1	LDLa	74..105	CDD:238060	3/30 (10%)
		SRCR_2	121..218	CDD:295335	19/96 (20%)
		Tryp_SPc	223..449	CDD:214473	84/245 (34%)
		Tryp_SPc	224..449	CDD:238113	83/244 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910