DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Np and tmprss4

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_012822151.1	Gene:	tmprss4 / 733869	XenbaseID:	XB-GENE-940762	Length:	785	Species:	Xenopus tropicalis

Alignment Length:	858	Identity:	236/858 - (27%)
Similarity:	344/858 - (40%)	Gaps:	192/858 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 RTTTAKPVLTTAPIVEQRIETTSVPTKFVTFQIVETTTPAVTEPTHQQETTTTTTRRHTRPTGSS 323
            |.|.|.|...:|....     ||.||:        |:.||.:.|.......:.|....|..:|..
Frog    41 RATAAVPTAVSAFTAH-----TSGPTR--------TSAPATSTPGPATSRPSGTPAPTTHNSGLI 92

  Fly   324 SVASRTTSKTTTTTTTTTTTTAAPPTTTSTRAATTTQRPTPPLRTTTSKPHKTHSSRRPAPAKKP 388
            |.||.||..|.||::|...|.....::...|:..||...|.|...|.|      ||..|
Frog    93 STASHTTGLTGTTSSTVNPTVPTASSSNIPRSMGTTANATNPTVPTAS------SSNIP------ 145

  Fly   389 VSTTTTTASGTQSTRKPADSLASGSTTANGTTATTLPARRPVTQTSSSS-------TTTTSTTST 446
             .:|.|||:.|..|...|.|  |....:.||||.   |..|...|:|||       ||..:|..|
Frog   146 -RSTGTTANATNPTVPTASS--SNIPRSTGTTAN---ATNPTVPTASSSNIPRSTGTTANATNPT 204

  Fly   447 ITTTVFKDELPKNRTTTRLPERT-TQAPRPRPK-PTGEIVKVPALL---AEPTTTTVTKGSS--- 503
            :.||          ::|.:|..| |.|....|. ||.....:|..|   |..|..||...||
Frog   205 VPTT----------SSTSIPRSTGTTANATNPTVPTASSTNIPRSLGTTANATNPTVPTASSTNI 259

  Fly   504 ------SSSSSSPKPPASSTTPLVTKKKPTTTNAPTTTTTTTTTTTTTTTPKPTRRTKPPTTTTT 562
                  :::|::|..|.:|:|. :.:...||.||...|..|.|...:|.||.|| ||..|||.|.
Frog   260 PRSSGTTANSTNPTVPTASSTN-IPRSSGTTANATNPTVPTRTPAASTHTPNPT-RTPVPTTHTP 322

  Fly   563 TTTKATTTTTKATTTTTTAKPLITT-----EPPTSAPLTTTTKKTGLITWTDVEAEP------PT 616
            ...:......:....:.|..|:..|     :||||.| |.|.||.        :|.|      ||
Frog   323 GPVRTPANAPRVPGPSRTPGPVRGTPRPVPKPPTSGP-TVTYKKE--------KAFPIRKYCVPT 378

  Fly   617 NASISNDWQPAPPSNWLPLTTESSETADKTSASTAPPSATDKVVIS-------VATSVSEVETHG 674
            .|.:            |.|            ||.|..:...|||:.       .:.....::...
Frog   379 VAVL------------LVL------------ASIAVIAILIKVVLDNYYFFCVKSFKFIPLDQWC 419

  Fly   675 PGKPQKTTKPPKPSSTAKPTTTTTAAATTIVKTTEAPASSIEL-ASSTSSYTDLGSDLAASSSSS 738
            .|| ...|.....|...:|...||   .:.|:..|| .|.::| ..:.||::.:.:|
Frog   420 DGK-SDCTGGEDESRCVQPFDVTT---NSNVRFAEA-GSVLQLYVQARSSWSFICND-------- 471

  Fly   739 TTTTTSSPTTAAETTDYSGEEPNTTTIEATGSTTVAPANALEGVDYKEV---------------- 787
            ...|..:....|:...||.....|.:|....:::....:.::.:..|.:
Frog   472 NWDTNKAKAVCAQVGFYSEPVSGTVSISDLSTSSALLYSTVQVLSDKSIQVNPTVWGSCTSGQVV 536

  Fly   788 ------CGRRMFPEPRIVGGANAAFGRWPWQISLRQWRTSTYL--HKCGAALLNENWAITAAHCV 844
                  ||.. ..:.||:||:|:...::|||:||:      |:  |.||.::||..|.:.||||.
Frog   537 SLRCAACGTG-HKQERIIGGSNSDILKYPWQVSLQ------YMGQHICGGSILNSRWILCAAHCF 594

  Fly   845 DNVPPSDLLLRLGEYDLAEEEEPYGYQERRVQIVASHPQFDPRTF---EY-------DLALLRFY 899
            |.          |:..:......||.    ..:......|..:.|   :|       |:|||:..
Frog   595 DR----------GQRQVDRWRVQYGI----TTLTYLFGTFVDKIFLNSKYVTDQKPNDIALLQLK 645

  Fly   900 EPVIFQPNIIPVCVPDNDENF-IGQTAFVTGWGRLYEDG-PLPSVLQEVAVPVINNTICESMYRS 962
            ..::...::.|||:|..|.|. :|...:|||||...|.| .|.|.|||||:.:|::|.|...|..
Frog   646 SDIVASASVQPVCLPGYDNNLVVGAVLYVTGWGHTVEGGAALASQLQEVAISLISSTTCNQEYGG 710

  Fly   963 AGYIEHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQPGVYTR 1027
                 .|....:|||...||.|:|:||||||:|...:| ..:...|::|||.||...|:.||||.
Frog   711 -----QILDTMLCAGKIAGGADTCQGDSGGPLVSLGQS-SHWEQVGIVSWGDGCGRPNRVGVYTD 769

  Fly  1028 ISEFRDWINQILQ 1040
            :..|.:||..:::
Frog   770 VQSFLNWIYGVMK 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	85/251 (34%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	86/253 (34%)
tmprss4	XP_012822151.1	ATF7IP_BD	<110..233	CDD:293393	44/150 (29%)
		PHA03193	<206..340	CDD:177555	41/145 (28%)
		LDLa	402..434	CDD:238060	4/32 (13%)
		SRCR_2	453..545	CDD:292133	13/99 (13%)
		SRCR	464..541	CDD:278931	9/84 (11%)
		Tryp_SPc	551..777	CDD:214473	85/251 (34%)
		Tryp_SPc	552..777	CDD:238113	84/250 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000