Protein Alignment Np and TMPRSS2

DIOPT Version :9

• Sequence 1: NP_001246213.1
• Gene: Np / 35904
• FlyBaseID: FBgn0265011
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_001128571.1
• Gene: TMPRSS2 / 7113
• HGNCID: 11876
• Length: 529
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 133/509 - (26%)
• Similarity: 187/509 - (36%)
• Gaps: 148/509 - (29%)

  Fly   629 PSNWLPLTTESSETADKTSASTAPPSATDKVVISVATSVSEVETHGPGKPQKTTKPPKPSSTAKP 693
            |.|..|.......|..:...:...||...:....|.|..|        .|...|:|..||.|...
Human    59 PENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQAS--------NPVVCTQPKSPSGTVCT 115

  Fly   694 TTTTTAAATTIVKTT------------------EAPASSIELASS-----TSSYTDLGSDLAASS 735
            :.|..|...|:...|                  :...|.||..||     .|::.|..|......
Human   116 SKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGE 180

  Fly   736 SSSTTTTTSSPTTAAETTDYSGEE------------------------------PNTTTIEATGS 770
            ..:.......|....:.  ||.:.                              .:...::.:||
Human   181 DENRCVRLYGPNFILQV--YSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGS 243

  Fly   771 TTVAPANALEG-VD-YKEV------------------CGRRM--FPEPRIVGGANAAFGRWPWQI 813
            |:....|...| || ||::                  ||..:  ..:.|||||.:|..|.||||:
Human   244 TSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQV 308

  Fly   814 SLRQWRTSTYLHKCGAALLNENWAITAAHCVDNVPPSDLLLRLGEYDLAEEEEPY---------- 868
            ||....    :|.||.:::...|.:||||||                    |:|.
Human   309 SLHVQN----VHVCGGSIITPEWIVTAAHCV--------------------EKPLNNPWHWTAFA 349

  Fly   869 ------------GYQERRVQIVASHPQFDPRTFEYDLALLRFYEPVIFQPNIIPVCVPD-----N 916
                        |||   |:.|.|||.:|.:|...|:||::..:|:.|...:.|||:|:     .
Human   350 GILRQSFMFYGAGYQ---VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQ 411

  Fly   917 DENFIGQTAFVTGWGRLYEDGPLPSVLQEVAVPVINNTICESMYRSAGYIEHIPHIFICAGWKKG 981
            .|    |..:::|||...|.|....||....|.:|....|.|.|   .|...|....||||:.:|
Human   412 PE----QLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRY---VYDNLITPAMICAGFLQG 469

  Fly   982 GYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQPGVYTRISEFRDWI 1035
            ..|||:||||||:|..:  :..:.|.|..|||.|||:|.:||||..:..|.|||
Human   470 NVDSCQGDSGGPLVTSK--NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	90/264 (34%)
		Tryp_SPc	798..1038	CDD:238113	91/265 (34%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625	6/31 (19%)
		LDLa	150..185	CDD:238060	8/34 (24%)
		SRCR_2	190..283	CDD:292133	13/94 (14%)
		Tryp_SPc	292..521	CDD:214473	90/264 (34%)
		Tryp_SPc	293..524	CDD:238113	91/265 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40690
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810