DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Np and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	370	Identity:	102/370 - (27%)
Similarity:	172/370 - (46%)	Gaps:	75/370 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 EAPASSIELASSTSSYTDLGSDLAAS---SSSSTTTTTSSPTTAAETTDYSGEEPNTTTIEATGS 770
            |.||.::.|:...|:...|  |.|..   |:.....|.:...||.....|| .:|....:|
Human    98 EGPAVAVRLSKDRSTLQVL--DSATGNWFSACFDNFTEALAETACRQMGYS-SKPTFRAVE---- 155

  Fly   771 TTVAPANALEGVDYKE-------------------------VCGRRMFPEPRIVGGANAAFGRWP 810
              :.|...|:.|:..|                         .||:.: ..||:||...|:...||
Human   156 --IGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSL-KTPRVVGVEEASVDSWP 217

  Fly   811 WQISLRQWRTSTYLHKCGAALLNENWAITAAHCVDNVPP---------SDLLLRLGEY-DLAEEE 865
            ||:|::..:.    |.||.::|:.:|.:|||||......         ||   :||.: .||
Human   218 WQVSIQYDKQ----HVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSD---KLGSFPSLA--- 272

  Fly   866 EPYGYQERRVQIVASHPQFDPRTFEYDLALLRFYEPVIFQPNIIPVCVPDNDENFIGQT-AFVTG 929
                  ..::.|:..:|.: |:  :.|:||::...|:.|...:.|:|:|..||.....| .::.|
Human   273 ------VAKIIIIEFNPMY-PK--DNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIG 328

  Fly   930 WGRLYED-GPLPSVLQEVAVPVINNTICESMYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGP 993
            ||...:: |.:..:|.:.:|.||::|.|.:   ...|...:....:|||..:||.|:|:||||||
Human   329 WGFTKQNGGKMSDILLQASVQVIDSTRCNA---DDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGP 390

  Fly   994 MVLQRESDKRFHLGGVISWGIGCAEANQPGVYTRISEFRDWINQI 1038
            ::.|.:   ::|:.|::|||.||...:.|||||::|.:.:||..:
Human   391 LMYQSD---QWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNV 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	77/249 (31%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	78/251 (31%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	16/97 (16%)
		Tryp_SPc	204..429	CDD:214473	77/249 (31%)
		Tryp_SPc	205..432	CDD:238113	78/251 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910