DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Np and tmprss2

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001008623.1	Gene:	tmprss2 / 494080	ZFINID:	ZDB-GENE-041212-48	Length:	486	Species:	Danio rerio

Alignment Length:	292	Identity:	111/292 - (38%)
Similarity:	147/292 - (50%)	Gaps:	33/292 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   755 YSGEE----PNTTTIEATGSTTVAPANALEGVDYKEVCGRRMFPEPRIVGGAN-AAFGRWPWQIS 814
            |||.:    |:...|.|..|:|   |.:|:..|    |||.  ...|||||.. .:.|.||||:|
Zfish   214 YSGYQGILSPSLDFISACQSST---AVSLKCTD----CGRS--TGNRIVGGTTVTSKGVWPWQVS 269

  Fly   815 LRQWRTSTYLHKCGAALLNENWAITAAHCVDNVP-PSDLLLRLGEYDLAEEEEPYGYQERRVQIV 878
            |..    :..|.||.:::...|.:||||||.... |....:..|....:|.....|....|:.|
Zfish   270 LHY----SGRHLCGGSIITPYWILTAAHCVHQFSNPGGWTVYAGYLTQSEMASASGNSVNRIVI- 329

  Fly   879 ASHPQFDPRTFEYDLALLRFYEPVIFQPNIIPVCVPDNDENFIG-QTAFVTGWGRLYEDGPLPSV 942
              | .|:|.|.|.|:||:|....:....||.|||:|:...:|.. |..:|||||.|:..|...:.
Zfish   330 --H-DFNPNTNENDIALMRLNTALTISTNIRPVCLPNKGMSFTAQQDCYVTGWGALFSGGSSSAT 391

  Fly   943 LQEVAVPVINNTICES--MYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFH 1005
            |||..:.:|::|||.|  :|...     |....||||...||.|||:||||||:|....|  .:.
Zfish   392 LQEAKIQLIDSTICNSRPVYNGL-----ITDTMICAGKLAGGVDSCQGDSGGPLVTNVRS--LWW 449

  Fly  1006 LGGVISWGIGCAEANQPGVYTRISEFRDWINQ 1037
            |.|..|||.|||..|:||||..::.|.|||.|
Zfish   450 LLGDTSWGDGCAVRNKPGVYGNVTYFLDWIYQ 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	94/242 (39%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	96/245 (39%)
tmprss2	NP_001008623.1	LDLa	132..168	CDD:238060
		SRCR_2	173..248	CDD:295335	14/42 (33%)
		Tryp_SPc	251..479	CDD:214473	94/242 (39%)
		Tryp_SPc	252..482	CDD:238113	96/245 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810