DRSC/TRiP Functional Genomics Resources

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Protein Alignment Np and LPA

DIOPT Version :10

Sequence 1:NP_610437.2 Gene:Np / 35904 FlyBaseID:FBgn0265011 Length:1041 Species:Drosophila melanogaster
Sequence 2:NP_005568.2 Gene:LPA / 4018 HGNCID:6667 Length:2040 Species:Homo sapiens


Alignment Length:1356 Identity:289/1356 - (21%)
Similarity:428/1356 - (31%) Gaps:477/1356 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 GTYTYTAASRAVEA-SDLTPKR-----------------------IGAPAIATSRMPLTSLVFSL 49
            |||:.|...|..:| |.:||..                       :.||...| |.|.....:..
Human   836 GTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYT-RDPSVRWEYCN 899

  Fly    50 LTLGSLMLLTADASPVFVDNPSLAQFQSGRNIRHLPCIVRKSGRSGICMFAIDCIKQNG-THLGT 113
            ||..|....||.|.|.....|||............|.:.             :|...|| ::.||
Human   900 LTQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQ-------------ECYHGNGQSYQGT 951

  Fly   114 CIDRFYF----GSCCAMKEEASLFAPEINDNSIDQNTISHFSHESTTLPTSALFKLTTESSLSSS 174
                 ||    |..|                                           ::..|.:
Human   952 -----YFITVTGRTC-------------------------------------------QAWSSMT 968

  Fly   175 SSSGSSTAHHHTTNELLKNVTQSYLSTAKPAPVRTTSNGTLSTTRRPPLAHTTHKNSHYVVRTTM 239
            ..|.|.|..::....|:||..::      |.||..            |..:||..:..:......
Human   969 PHSHSRTPAYYPNAGLIKNYCRN------PDPVAA------------PWCYTTDPSVRWEYCNLT 1015

  Fly   240 KPSAAPTTTITPTVKPPRRRTTTAKPVLTTAPIVEQRIE-----------------------TTS 281
            :.|.|..|...|             |.:..||.:|...|                       |.|
Human  1016 RCSDAEWTAFVP-------------PNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYS 1067

  Fly   282 VPTKFVTFQIVETTTPAVTEPTHQQETTTTTTRRHTR--------------PTGSSSVASRTTSK 332
            ......|.|...:.||.....|.:.......||.:.|              |:......:.|...
Human  1068 TTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCL 1132

  Fly   333 TTTTTTTTTTTTAAPPTT-TSTRAATTTQRPTPP--------------LRTTTSKPHKTHSSRRP 382
            .|.::...|.|....|:| .|:..|.|.|.|...              ..|.|.:..::.||..|
Human  1133 VTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTP 1197

  Fly   383 APAKKPVSTTTTTASG--TQS-TRKPADSLASGSTTANG--------------------TTATTL 424
            ...::   ||....:|  |:: .|.|...::....|.:.                    .|:|.:
Human  1198 HWHQR---TTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAV 1259

  Fly   425 PARRPVTQT---------------SSSSTTTTSTT----STIT------TTVFKDELPKNRTTTR 464
            ..:.|..|:               .|.|||.|..|    |::|      ||.:.......|...|
Human  1260 SEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCR 1324

  Fly   465 LPE-------------------RTTQAPRPRPKPTGEIVKVPALLAEPTTTTVTKGSSSSSSSSP 510
            .|:                   ..||.|          |....||..||...|    .|:...|.
Human  1325 NPDAEIRPWCYTMDPSVRWEYCNLTQCP----------VMESTLLTTPTVVPV----PSTELPSE 1375

  Fly   511 KPPASSTTPLVTKKKPTTTNAPTTTTTTTTTTT----TTTTPKPTRR------------------ 553
            :.|..::|.:....:....:...|.:||.|..|    ::.||...||                  
Human  1376 EAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNP 1440

  Fly   554 ---------TKPPTT--TTTTTTKATTTTTKATTTTTTAKPLITTE------PPTSAPL------ 595
                     |..|:.  .....|:...|.:...||.|.| |:.:||      ||..:|:      
Human  1441 DAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVA-PVPSTEAPSEQAPPEKSPVVQDCYH 1504

  Fly   596 -----------TTTTKKT-----GLIT-WTDVEAEPPTNASISNDWQPAPPSN---WLPLT---- 636
                       ||.|.:|     .:|. |.....|...||.::.::...|.|.   |...|    
Human  1505 GDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQPWCYTTDPCV 1569

  Fly   637 -------TESSETAD---KTSASTAPPS--ATDKVVISVATSVSEVETHGPGK------------ 677
                   |:.|||..   :|......||  |..:...:..|.|.....||.|:            
Human  1570 RWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTG 1634

  Fly   678 ----------PQKTTKPPK--------------PSSTAKPTTTT------------TAAATTIVK 706
                      |.:..:.|:              |.:...|...|            |..:.| ..
Human  1635 RTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCNLTRCSDT-EG 1698

  Fly   707 TTEAPASSIELAS--STSSYTDLGSDLAASSSSSTTTTTSSPTTAAETTDYSGEEPNTTTIEATG 769
            |..||.:.|::.|  ..|....:..:.........||.|.:|     ..:::.:||:..:....|
Human  1699 TVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTP-----CQEWAAQEPHRHSTFIPG 1758

  Fly   770 STTVA---------PANALEG-----------VDYKEV---------CGRRMFPEPR-----IVG 800
            :...|         |...:.|           .||.::         ||:... ||:     |||
Human  1759 TNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKPQV-EPKKCPGSIVG 1822

  Fly   801 GANAAFGRWPWQISLRQWRTSTYLHKCGAALLNENWAITAAHCV-DNVPPSDLLLRLGEYDLAEE 864
            |..|....||||:||   ||....|.||..|::..|.:|||||: .:..||...:.||       
Human  1823 GCVAHPHSWPWQVSL---RTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILG------- 1877

  Fly   865 EEPYGYQERRVQIVASHPQ--------FDPRTFEYDLALLRFYEPVIFQPNIIPVCVPDNDENFI 921
                .:||..::   ||.|        .:|.  :.|:|||:...|.:....::|.|:|..|....
Human  1878 ----AHQEVNLE---SHVQEIEVSRLFLEPT--QADIALLKLSRPAVITDKVMPACLPSPDYMVT 1933

  Fly   922 GQT-AFVTGWGRLYEDGPL-PSVLQEVAVPVINNTICESMYRSAGYIEHIPHIFICAGWKKGGYD 984
            .:| .::||||.  ..|.. ..:|:|..:.||.|.:| :.|:           :|||.....|.|
Human  1934 ARTECYITGWGE--TQGTFGTGLLKEAQLLVIENEVC-NHYK-----------YICAEHLARGTD 1984

  Fly   985 SCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQPGVYTRISEFRDWINQILQ 1040
            ||:||||||:|. .|.|| :.|.||.|||:|||..|:||||.|:|.|..||..:::
Human  1985 SCQGDSGGPLVC-FEKDK-YILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMR 2038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NpNP_610437.2 Tryp_SPc 798..1038 CDD:238113 91/250 (36%)
LPANP_005568.2 Kringle 28..105 CDD:395005
Kringle 142..219 CDD:395005
Kringle 256..333 CDD:395005
Kringle 370..447 CDD:395005
Kringle 484..561 CDD:395005
Kringle 598..675 CDD:395005
Kringle 712..789 CDD:395005
Kringle 826..903 CDD:395005 16/67 (24%)
KR 938..1019 CDD:214527 22/159 (14%)
Kringle 1054..1131 CDD:395005 12/76 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1166 7/18 (39%)
KR 1166..1246 CDD:214527 12/82 (15%)
KR 1272..1352 CDD:214527 15/79 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1365..1388 5/26 (19%)
KR 1386..1466 CDD:214527 12/79 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1476..1497 7/21 (33%)
KR 1500..1581 CDD:214527 14/80 (18%)
KR 1614..1695 CDD:214527 9/80 (11%)
Kringle 1720..1799 CDD:395005 12/83 (14%)
Tryp_SPc 1820..2034 CDD:238113 90/248 (36%)
Blue background indicates that the domain is not in the aligned region.

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