DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Np and KLKB1

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	389	Identity:	110/389 - (28%)
Similarity:	177/389 - (45%)	Gaps:	81/389 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 IVKTTEA--PASSIELASSTSSYTDLGSDLAASSSSSTTTTTSSPTTAAETTDYSGEEPNTTTIE 766
            ::||:|:  |:||....::.|.|:.|        :...|......:......|:.|||.|.|.::
Human   268 LLKTSESGTPSSSTPQENTISGYSLL--------TCKRTLPEPCHSKIYPGVDFGGEELNVTFVK 324

  Fly   767 AT---------------------------------------GSTTVAPANALEGVDY-------- 784
            ..                                       ||.|...........|
Human   325 GVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTG 389

  Fly   785 -KEVCGRRMFPEPRIVGGANAAFGRWPWQISLRQWRTSTYLHKCGAALLNENWAITAAHCVDNVP 848
             ..||..:  ...|||||.|:::|.||||:|| |.:.:...|.||.:|:...|.:|||||.|.:|
Human   390 DNSVCTTK--TSTRIVGGTNSSWGEWPWQVSL-QVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLP 451

  Fly   849 PSDL------LLRLGEYDLAEEEEPYGYQERRVQIVASHPQFDPRTFEYDLALLRFYEPVIFQPN 907
            ..|:      :|.|.:   ..::.|:.    :::.:..|..:......:|:||::...|:.:...
Human   452 LQDVWRIYSGILNLSD---ITKDTPFS----QIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEF 509

  Fly   908 IIPVCVPD-NDENFIGQTAFVTGWGRLYEDGPLPSVLQEVAVPVINNTICESMYRSAGYIEHIPH 971
            ..|:|:|. .|.:.|....:|||||...|.|.:.::||:|.:|::.|..|:..|:.    ..|..
Human   510 QKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQD----YKITQ 570

  Fly   972 IFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQPGVYTRISEFRDWI 1035
            ..:|||:|:||.|:|:||||||:|.:...  .:.|.|:.|||.|||...||||||:::|:.|||
Human   571 RMVCAGYKEGGKDACKGDSGGPLVCKHNG--MWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	86/244 (35%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	87/245 (36%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519	9/34 (26%)
		APPLE	303..386	CDD:128519	10/82 (12%)
		Tryp_SPc	401..632	CDD:214473	86/244 (35%)
		Tryp_SPc	402..632	CDD:238113	85/243 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810