DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Np and tmprss4b

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001119849.1	Gene:	tmprss4b / 327651	ZFINID:	ZDB-GENE-030131-5862	Length:	432	Species:	Danio rerio

Alignment Length:	351	Identity:	109/351 - (31%)
Similarity:	173/351 - (49%)	Gaps:	70/351 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 TTIVKTTEAPASSI------ELA--SSTSSYTDLGSDLAASSSSSTTTTTSSPTTAAETTDYSGE 758
            |...::|..|..|:      |.|  |:.|:.:|:.|.|:||:..|:.:..|...:
Zfish   137 TVSPRSTRIPVRSLFFNPQNEFATVSNDSAQSDIQSFLSASNKCSSGSVVSVSCS---------- 191

  Fly   759 EPNTTTIEATGSTTVAPANALEGVDYKEVCGRRMFPEPRIVGGANAAFGRWPWQISLRQWRTSTY 823
                                    |..||.|     |.|||||...:...||||:||:    ..:
Zfish   192 ------------------------DCGEVVG-----EDRIVGGVETSIEHWPWQVSLQ----FNH 223

  Fly   824 LHKCGAALLNENWAITAAHCVDNVPP--SDLLLRLGEYDLAEEEEPYGYQERRVQIVASHPQFDP 886
            .|.||.:||:.:|.|:||||......  |...:.||:   .:..:..|..   |.::..|..::.
Zfish   224 RHMCGGSLLSTSWIISAAHCFTGRTQELSRWTVVLGQ---TKVMDVVGVS---VDMIVIHKDYNR 282

  Fly   887 RTFEYDLALLRFYEPVIFQPNIIPVCVPDNDENFIGQTAFVTGWGRLYEDGPLPSVLQEVAVPVI 951
            .|.::|:|:|:...||....:|:|||:|.: :..|.....|||||.|.|.|.||:|||:.:||::
Zfish   283 LTNDFDIAMLKLTWPVKTGESILPVCLPPH-QLAIKDMLVVTGWGLLKEGGALPTVLQKASVPLV 346

  Fly   952 NNTICE--SMYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGI 1014
            |.:.|.  ::|.|:     |....:|||:.:|..|:|:||||||:|.   ...|:.|.|::|||:
Zfish   347 NRSECSKPTIYSSS-----ITPRMLCAGFLQGNVDACQGDSGGPLVY---LSSRWQLIGIVSWGV 403

  Fly  1015 GCAEANQPGVYTRISEFRDWINQILQ 1040
            |||...:||||..:::..|||..:::
Zfish   404 GCAREGKPGVYADVTQLLDWIYTVME 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	87/241 (36%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	88/243 (36%)
tmprss4b	NP_001119849.1	SRCR_2	100..179	CDD:292133	13/41 (32%)
		SRCR	105..>175	CDD:278931	10/37 (27%)
		Tryp_SPc	201..424	CDD:214473	87/241 (36%)
		Tryp_SPc	202..427	CDD:238113	88/243 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810