Protein Alignment Np and HPN

DIOPT Version :10

• Sequence 1: NP_610437.2
• Gene: Np / 35904
• FlyBaseID: FBgn0265011
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 131/439 - (29%)
• Similarity: 198/439 - (45%)
• Gaps: 76/439 - (17%)

  Fly   643 ADKTSASTAPPSATDKVVISVATSVSEVETHGPGKPQKTTKPPKPSSTAKPTTTTTAAATTIVKT 707
            |.|....|.|..:..||....|.::..:...|                    ..:.|....::::
Human     2 AQKEGGRTVPCCSRPKVAALTAGTLLLLTAIG--------------------AASWAIVAVLLRS 46

  Fly   708 TEAPASSIELASSTS---------------------------SYTDLGSDLAASSSSSTTTTTSS 745
            .:.|...::::|:.:                           |..::|...|.:.|.....|..:
Human    47 DQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGA 111

  Fly   746 PTTAAETTDYSGEEPNTTTIEATGSTTVAPANALEGVDYKEVCGRRMFPEPRIVGGANAAFGRWP 810
            ..|:.......|..|:|..:....|....|.........:: ||||..|..|||||.:.:.||||
Human   112 NGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQD-CGRRKLPVDRIVGGRDTSLGRWP 175

  Fly   811 WQISLRQWRTSTY--LHKCGAALLNENWAITAAHCVDNVPPSDLLL---RLGEYDLAEEEEPYGY 870
            ||:|||      |  .|.||.:||:.:|.:|||||   .|..:.:|   |:....:| :..|:|.
Human   176 WQVSLR------YDGAHLCGGSLLSGDWVLTAAHC---FPERNRVLSRWRVFAGAVA-QASPHGL 230

  Fly   871 QERRVQIVASH----PQFDPRTFE--YDLALLRFYEPVIFQPNIIPVCVPDNDENFI-GQTAFVT 928
            | ..||.|..|    |..||.:.|  .|:||:....|:.....|.|||:|...:..: |:...||
Human   231 Q-LGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVT 294

  Fly   929 GWGRLYEDGPLPSVLQEVAVPVINNTICESMYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGP 993
            |||.....|....||||..||:|:|.:|.........|:  |.:| |||:.:||.|:|:||||||
Human   295 GWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIK--PKMF-CAGYPEGGIDACQGDSGGP 356

  Fly   994 MVLQRESDK--RFHLGGVISWGIGCAEANQPGVYTRISEFRDWINQILQ 1040
            .|.:....:  |:.|.|::|||.|||.|.:|||||::|:||:||.|.::
Human   357 FVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_610437.2	Tryp_SPc	798..1038	CDD:238113	102/253 (40%)
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	16/108 (15%)
		Tryp_SPc	163..400	CDD:238113	100/250 (40%)