DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Np and Tmprss4

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_663378.1	Gene:	Tmprss4 / 214523	MGIID:	2384877	Length:	435	Species:	Mus musculus

Alignment Length:	359	Identity:	103/359 - (28%)
Similarity:	171/359 - (47%)	Gaps:	53/359 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 EAPASSIELASSTSSYTDLGSDLAASSSSST---TTTTSSPTTAAETTDYSGE----------EP 760
            |.|..::.|:...|:...|  |.|..:.:|.   ..|.:...||.....|..:          :.
Mouse    96 EKPGVAVRLSKDRSTLQVL--DAATGTWASVCFDNFTEALAKTACRQMGYDSQPAFRAVEIRPDQ 158

  Fly   761 NTTTIEATGSTTVAPAN------------ALEGVDYKEVCGRRMFPEPRIVGGANAAFGRWPWQI 813
            |....:.||::......            :|..:|    ||:.: ..||:|||..|....||||:
Mouse   159 NLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLD----CGKSL-KTPRVVGGVEAPVDSWPWQV 218

  Fly   814 SLRQWRTSTYLHKCGAALLNENWAITAAHCVDN-VPPSDLLLRLGEYDLAEEEE-PYGYQERRVQ 876
            |::..:.    |.||.::|:.:|.:|||||... :..|...:|.|...|..... |..    ::.
Mouse   219 SIQYNKQ----HVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVA----KIF 275

  Fly   877 IVASHPQFDPRTFEYDLALLRFYEPVIFQPNIIPVCVPDNDENFIGQT-AFVTGWGRLYED-GPL 939
            |...:|.: |:  |.|:||::...|:.|..::.|:|:|.:||..:..| .:|.|||...|: |.:
Mouse   276 IAEPNPLY-PK--EKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKM 337

  Fly   940 PSVLQEVAVPVINNTICESMYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRF 1004
            ..:|.:.:|.||::|.|.:   ...|...:....:|||..:||.|:|:||||||  |...||| :
Mouse   338 SDMLLQASVQVIDSTRCNA---EDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGP--LMYHSDK-W 396

  Fly  1005 HLGGVISWGIGCAEANQPGVYTRISEFRDWINQI 1038
            .:.|::|||.||...:.|||||:::.:.:||..:
Mouse   397 QVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNV 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	81/241 (34%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	82/243 (34%)
Tmprss4	NP_663378.1	LDLa	56..90	CDD:238060
		SRCR_2	106..195	CDD:295335	14/94 (15%)
		Tryp_SPc	202..427	CDD:214473	81/241 (34%)
		Tryp_SPc	203..430	CDD:238113	82/243 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910