DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Np and Tmprss15

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_032967.1	Gene:	Tmprss15 / 19146	MGIID:	1197523	Length:	1069	Species:	Mus musculus

Alignment Length:	333	Identity:	108/333 - (32%)
Similarity:	171/333 - (51%)	Gaps:	28/333 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 ELASSTSSYTDLGSDLAASSSSSTTTTTSSPTTAAETTDYSGEEPNTTTIEATGSTTVAPANALE 780
            ::::.......|||   |:||...::|...|....      .:.||.:.|..........:..|.
Mouse   755 QISNEVCHLLGLGS---ANSSMPISSTGGGPFVRV------NQAPNGSLILTPSLQCSQDSLILL 810

  Fly   781 GVDYKEVCGRRMFPE---PRIVGGANAAFGRWPWQISLRQWRTSTYLHKCGAALLNENWAITAAH 842
            ..::|. ||.:...:   |:||||::|..|.|||.::|.....||....|||:|::.:|.::|||
Mouse   811 QCNHKS-CGEKKVTQKVSPKIVGGSDAQAGAWPWVVALYHRDRSTDRLLCGASLVSSDWLVSAAH 874

  Fly   843 CV--DNVPPSDLLLRLGEYDLAEEEEPYGYQERRVQIVASHPQFDPRTFEYDLALLRFYEPVIFQ 905
            ||  .|:.|:.....||.:..:....|. ...|.|..:..:|.:|.|....|:|::.....|.:.
Mouse   875 CVYRRNLDPTRWTAVLGLHMQSNLTSPQ-VVRRVVDQIVINPHYDRRRKVNDIAMMHLEFKVNYT 938

  Fly   906 PNIIPVCVPDNDENFI-GQTAFVTGWGRLYED---GPLPSVLQEVAVPVINNTICESMYRSAGYI 966
            ..|.|:|:|:.::.|| |:|..:.|||  |:.   |....||:|..||:|:|..|:.........
Mouse   939 DYIQPICLPEENQIFIPGRTCSIAGWG--YDKINAGSTVDVLKEADVPLISNEKCQQQLPEYNIT 1001

  Fly   967 EHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQPGVYTRISEF 1031
            |.:    ||||:::||.|||:||||||::.|  .:.|:.|.||.|:|:.||..|.||||.|:|:|
Mouse  1002 ESM----ICAGYEEGGIDSCQGDSGGPLMCQ--ENNRWFLVGVTSFGVQCALPNHPGVYVRVSQF 1060

  Fly  1032 RDWINQIL 1039
            .:||:..|
Mouse  1061 IEWIHSFL 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	89/243 (37%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	91/245 (37%)
Tmprss15	NP_032967.1	SEA	53..154	CDD:214554
		LDLa	228..261	CDD:197566
		CUB	270..376	CDD:294042
		MAM	392..549	CDD:279023
		MAM	392..547	CDD:99706
		CUB	569..676	CDD:278839
		LDLa	688..722	CDD:238060
		SR	723..816	CDD:214555	12/69 (17%)
		SRCR	728..819	CDD:278931	14/73 (19%)
		Tryp_SPc	829..1064	CDD:214473	89/243 (37%)
		Tryp_SPc	830..1066	CDD:238113	91/244 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860