DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Np and svh-1

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_501379.2	Gene:	svh-1 / 182375	WormBaseID:	WBGene00006620	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	134/502 - (26%)
Similarity:	198/502 - (39%)	Gaps:	153/502 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   660 VISVATSVSEVETH------GPGKPQKTTKPP------KPSSTAKPTTTTTAA------------ 700
            |:.....:..||:|      ||.:|  ||..|      .|||.::...|:.:|
Worm   476 VLGFGDPIYTVESHQSESSLGPLQP--TTLHPTNPSFDSPSSVSQMRRTSPSATLAPRLPAWNLS 538

  Fly   701 -------ATTIVKTTE--------------------------------------APASSIEL--A 718
                   .:|::.|.|                                      ..|:|..|  .
Worm   539 CLREPNCTSTVISTCEPIRCSHCQQAACGDGSCIRFDQLCNGQIDCQSGEDEDYCRANSFRLTNG 603

  Fly   719 SSTSSYTD--------------LGSDLAASSSS-----------STTTTTSSPTTAAETTDYSGE 758
            |.||.|.:              |...::.|...           ||..|.||........|.|..
Worm   604 SDTSGYLEVLFRSRWEPICADHLNGKISNSICDAMRLGEHGFILSTNATISSGYNVNCDVDCSIR 668

  Fly   759 EPNTTT-------IEATGSTTVAPANALEGVDYKEVCGRRMFPE--PRIVGGANAAFGRWPWQIS 814
            ..::.|       |...|.::.:..    |:.|.||..|.....  .|:|||.....|.:||..:
Worm   669 RSSSCTRHARISCISQNGMSSASQC----GLRYVEVNARDAAKSRIARVVGGFETVPGAFPWTAA 729

  Fly   815 LRQWRTSTYLHKCGAALLNENWAITAAHCV-DNVPPSDLLLRLGEYD--LAEEEEPYGYQERRVQ 876
            ||  ..:|..|.|||::|::...||||||. ::...|...:.:|::|  ..:..|...|.:|
Worm   730 LR--NKATKAHHCGASILDKTHLITAAHCFEEDERVSSYEVVVGDWDNNQTDGNEQIFYLQR--- 789

  Fly   877 IVASHPQFDPRTFEYDLALLRF-YEPVIFQPNIIPVCVPDNDENFI---GQTAFVTGWGRL---Y 934
             :..:|.:.. .|.:|:|:|.. |..:.|.....|:|:|..|  |:   |:...|:|||.:   |
Worm   790 -IHFYPLYKD-IFSHDIAILEIPYPGIEFNEYAQPICLPSKD--FVYTPGRQCVVSGWGSMGLRY 850

  Fly   935 EDGPLPSVLQEVAVPVINNTIC-------ESMYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGG 992
            .:.     ||...:|:||...|       .||.|||          .|||:.:||.|||:|||||
Worm   851 AER-----LQAALIPIINRFDCVNSSQIYSSMSRSA----------FCAGYLEGGIDSCQGDSGG 900

  Fly   993 PMVLQRESDKRFHLGGVISWGIGCAEANQPGVYTRISEFRDWINQIL 1039
            |...:|| |..|.|.||||||.|||:..|||:||.::.:..||:.|:
Worm   901 PFACRRE-DGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWISAII 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	89/254 (35%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	90/256 (35%)
svh-1	NP_501379.2	KR	227..306	CDD:214527
		LDLa	320..355	CDD:238060
		PAN_AP_HGF	373..434	CDD:238532
		LDLa	558..590	CDD:197566	0/31 (0%)
		SRCR_2	599..681	CDD:382996	15/81 (19%)
		Tryp_SPc	713..945	CDD:238113	90/256 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910