Protein Alignment Np and TMPRSS6

DIOPT Version :10

• Sequence 1: NP_610437.2
• Gene: Np / 35904
• FlyBaseID: FBgn0265011
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_001275929.1
• Gene: TMPRSS6 / 164656
• HGNCID: 16517
• Length: 824
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 99/278 - (35%)
• Similarity: 143/278 - (51%)
• Gaps: 39/278 - (14%)

  Fly   788 CGRRMFPEPRIVGGANAAFGRWPWQISLRQWRTSTYLHKCGAALLNENWAITAAHCVDNVPPSDL 852
            ||.: .|..||||||.::.|.||||.|| |.|..   |.||.||:.:.|.||||||......:..
Human   559 CGLQ-GPSSRIVGGAVSSEGEWPWQASL-QVRGR---HICGGALIADRWVITAAHCFQEDSMAST 618

  Fly   853 LL---RLGEYDLAEEEEPYGYQERRVQIVASHPQFDPRTFEYDLALLRFYEPVIFQPNIIPVCVP 914
            :|   .||:  :.:.....|....:|..:..||..:..:.:||:|||:...||:....:.|||:|
Human   619 VLWTVFLGK--VWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLP 681

  Fly   915 DNDENF-IGQTAFVTGWGRLYEDG----------------------PLPSVLQEVAVPVINNTIC 956
            .....| .|...::||||.|.|..                      |:.:.||:|.|.:|...:|
Human   682 ARSHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQDLC 746

  Fly   957 ESMYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQ 1021
            ..:||    .:..|.: :|||::||..|:|:||||||:|.:..|. |:.|.|::|||:||...|.
Human   747 SEVYR----YQVTPRM-LCAGYRKGKKDACQGDSGGPLVCKALSG-RWFLAGLVSWGLGCGRPNY 805

  Fly  1022 PGVYTRISEFRDWINQIL 1039
            .||||||:....||.|::
Human   806 FGVYTRITGVISWIQQVV 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_610437.2	Tryp_SPc	798..1038	CDD:238113	94/265 (35%)
TMPRSS6	NP_001275929.1	SEA	77..>134	CDD:460188
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:395011
		Tryp_SPc	568..822	CDD:238113	94/265 (35%)