DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Np and Tmprss2

DIOPT Version :9

Sequence 1:	NP_001246213.1	Gene:	Np / 35904	FlyBaseID:	FBgn0265011	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_008766769.1	Gene:	Tmprss2 / 156435	RGDID:	620766	Length:	580	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	136/476 - (28%)
Similarity:	201/476 - (42%)	Gaps:	79/476 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   624 WQPAPPSNWLPLTTESSETADKTSASTAPPSATDKVVISVATSVSEVETHGPGKPQKTTKPPKPS 688
            :.|.|     |::..........|..:..|....:|....:|....::....| ...|:|..|..
  Rat    26 YSPRP-----PVSPSGYNLYPAQSCPSPVPQYAPRVTTQASTPAIHIQPRSSG-TLCTSKSKKSM 84

  Fly   689 STAKPTTTTTA----AATTIVKTTEAPASSIELASSTSSYTDLGSDLAAS--------------- 734
            ..|....|..|    ||..:.|..::..||.|:... ||.|.:.|.|...
  Rat    85 LVALALGTVLAGAAVAAGLLWKFWDSKCSSSEMECG-SSGTCISSSLWCDGVSQCPNGEDENRCV 148

  Fly   735 ---SSSSTTTTTSSP-----------------TTAAETTDYSGEEPNTTTI-EATGSTTVAPANA 778
               .:|.|....||.                 ..|.:...|.....::..| :.:|:|:....|.
  Rat   149 RLYGTSFTLQVYSSQRKAWYPVCQDDWNESYGRAACKDMGYKNSFYSSQGIPDQSGATSFMKLNV 213

  Fly   779 LEG-VD-YKEV------------------CG-RRMFPEPRIVGGANAAFGRWPWQISLRQWRTST 822
            ..| || ||::                  || |.:..:.|||||:.|:.|.||||:||.    ..
  Rat   214 SAGNVDLYKKLYHSDSCSSRMVVSLRCIECGVRSVRRQSRIVGGSTASPGDWPWQVSLH----VQ 274

  Fly   823 YLHKCGAALLNENWAITAAHCVDNVPPSDLLLRLGEYDLAEEEEPYGYQERRVQIVASHPQFDPR 887
            .:|.||.:::...|.:||||||:....|..........|.:....|| ...:|:.|.|||.:|.:
  Rat   275 GIHVCGGSIITPEWIVTAAHCVEEPLSSPRYWTAFAGILKQSLMFYG-SRHQVEKVISHPNYDSK 338

  Fly   888 TFEYDLALLRFYEPVIFQPNIIPVCVPDNDENF-IGQTAFVTGWGRLYEDGPLPSVLQEVAVPVI 951
            |...|:||::...|:.|...:.|||:|:..... :.|..:::|||..||.|....||....||:|
  Rat   339 TKNNDIALMKLQTPLAFNDVVKPVCLPNPGMMLDLAQECWISGWGATYEKGKTSDVLNAAMVPLI 403

  Fly   952 NNTICESMYRSAGYIEHIPHIFICAGWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGC 1016
            ..:.|.|.|.   |...|....||||:.:|..|||:||||||:|..:  ::.:.|.|..|||.||
  Rat   404 EPSKCNSKYI---YNNLITPAMICAGFLQGSVDSCQGDSGGPLVTLK--NEIWWLIGDTSWGSGC 463

  Fly  1017 AEANQPGVYTRISEFRDWINQ 1037
            |:|.:||||..::.|.|||.|
  Rat   464 AKAYRPGVYGNVTVFTDWIYQ 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_001246213.1	Tryp_SPc	797..1035	CDD:214473	90/238 (38%)
Np	NP_001246213.1	Tryp_SPc	798..1038	CDD:238113	92/241 (38%)
Tmprss2	XP_008766769.1	LDLa	112..147	CDD:238060	8/35 (23%)
		SRCR_2	152..247	CDD:292133	17/94 (18%)
		Tryp_SPc	253..482	CDD:214473	90/238 (38%)
		Tryp_SPc	254..485	CDD:238113	92/241 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9079
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810