Protein Alignment Np and tmprss2.2

DIOPT Version :10

• Sequence 1: NP_610437.2
• Gene: Np / 35904
• FlyBaseID: FBgn0265011
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: XP_002941330.2
• Gene: tmprss2.2 / 100493729
• XenbaseID: XB-GENE-22065949
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 579
• Identity: 139/579 - (24%)
• Similarity: 228/579 - (39%)
• Gaps: 102/579 - (17%)

  Fly   492 EPTTTTVTKGSSSSSSSSPKPPASSTTPLVTKKKPTTTNAPTTTTTTTTTTTTTTTPKPTRRTKP 556
            ||....:.  .|::....|.||.....|..|..||    :|...|....:....        .:|
 Frog     2 EPNVYVIP--PSNNDYELPPPPPYEPPPYTTVPKP----SPPPYTAQVQSGQFV--------ARP 52

  Fly   557 PTTTTTTTTKATTTTTKATTTTTTAK-------PLITTEPPTSAPLTTTTKKTGLITWTDVEA-- 612
            |.|.:|.|.:..............|.       ..:.|:.|::.|.|.|.:.....|:|.:.|
 Frog    53 PITPSTGTRRRRICIISFIVICKVAAIVAGLIIGFVVTKRPSTTPSTPTCQMYCSYTYTCIHAYQ 117

  Fly   613 --EPPTNASISNDWQPAPPSNWLPLTTE-----------SSETADKTSASTAPPSATDKVVISVA 664
              :...:....:|.:....:  ||...|           ||:..|  ..|..|....:...:.:.
 Frog   118 ICDGVQDCRYGDDERNCGAT--LPANCEKRCGSSVSCVRSSQWCD--GVSQCPNGEDETSCVRLY 178

  Fly   665 TSVSEVETHGPGKPQKTTKPPKPSSTAKPTTTTTAAATTIVKTTEAPASSIELASSTSSYT--DL 727
            .:.|:::.:                             :.:|:...|..:...:.:...:.  |.
 Frog   179 GADSQLQVY-----------------------------STLKSAWLPVCADNWSDAYGRFACRDF 214

  Fly   728 GSDLAASSSSSTTTTTSSPTTAAETTDYSGEEPNTTTIEATGSTTVAPANALE----GVDYKEVC 788
            |...::.:.|:|..:..:|....:..:..|.....|:::.:.|.......:|.    ||.|..|.
 Frog   215 GYSGSSYNRSNTLPSPYAPNGYFKLNNGFGSSQFYTSVQNSSSCFSGNVVSLRCISCGVSYNSVA 279

  Fly   789 GRRMFPEPRIVGGANAAFGRWPWQISLRQWRTSTYLHKCGAALLNENWAITAAHCVDN-----VP 848
            .       |||||..||:|.|.||:.|| :.|...   ||.::::..|.:||||||..     :.
 Frog   280 S-------RIVGGTYAAYGNWLWQVGLR-YNTGIL---CGGSIISPKWIVTAAHCVYGTDGFLLS 333

  Fly   849 PSDLLLRLGEYDLAEEEEPYGYQERRVQIVASHPQFDPRTFEYDLALLRFYEPVIFQPNIIPVCV 913
            .|...:..|...|....:..||   .|:.:..||.:...:.:.|:||:.....:.|..|..|||:
 Frog   334 ASGWRVFAGTLTLPSYYDSSGY---LVERIIPHPGYKTSSNDNDIALMELSNGITFGYNTQPVCL 395

  Fly   914 PDNDENF--IGQTAFVTGWGRLYEDGPLPSVLQEVAVPVINNTICESMYRSAGYIEHIPHIFICA 976
            | |...|  .|...:::|||...:.|...:.||..||.:|::.:|...|   .|...|....|||
 Frog   396 P-NAGMFWSSGTPCWISGWGTTSQGGSASTYLQYAAVQLIDSNVCNQNY---VYNGQITASMICA 456

  Fly   977 GWKKGGYDSCEGDSGGPMVLQRESDKRFHLGGVISWGIGCAEANQPGVYTRISEFRDWI 1035
            |:..||.|||:||||||:|  .:::..:.|.|..|||.|||:.|:||||..::.|..||
 Frog   457 GYLSGGVDSCQGDSGGPLV--TKTNGTWWLVGDTSWGYGCAQPNKPGVYGNMTSFLGWI 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Np	NP_610437.2	Tryp_SPc	798..1038	CDD:238113	87/245 (36%)
tmprss2.2	XP_002941330.2	LDLa	<111..134	CDD:238060	3/22 (14%)
		LDLa	145..174	CDD:238060	5/30 (17%)
		SRCR_2	179..274	CDD:464747	13/123 (11%)
		Tryp_SPc	282..513	CDD:238113	85/243 (35%)