DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and TMPRSS11D

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_004253.1	Gene:	TMPRSS11D / 9407	HGNCID:	24059	Length:	418	Species:	Homo sapiens

Alignment Length:	283	Identity:	105/283 - (37%)
Similarity:	143/283 - (50%)	Gaps:	27/283 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1419 STSRTLPTPNLAFHSPSTECGVRPH---VKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKC 1480
            ||..|..|...|.:....|||..|.   :...||:||..:..|::||||.:|      |...:.|
Human   154 STEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLR------LNNAHHC 212

  Fly  1481 GGVLITSRYVITAAHC-----QPGFLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPAT 1540
            ||.||.:.:::|||||     .|   ...:|..|   ||......|   ..|:.:::|..|..||
Human   213 GGSLINNMWILTAAHCFRSNSNP---RDWIATSG---ISTTFPKLR---MRVRNILIHNNYKSAT 268

  Fly  1541 FENDLALLELDSPVQFDTHIVPICMPNDVADF-TGRMATVTGWGRLKYGGGVPSVLQEVQVPIIE 1604
            .|||:||:.|::.|.|...|..:|:|....:. .|..|.|||||..:|.|.....|::.||.||.
Human   269 HENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIIS 333

  Fly  1605 NSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAA 1669
            |.||... |:  :|..||:..||||...|..|:|:||||||||.:.....:.:.|.||.|.:|..
Human   334 NDVCNAP-HS--YNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGL 395

  Fly  1670 PYLPGVYMRTTFYKPWLRSITGV 1692
            |..||||.|.|.|..|:|..||:
Human   396 PDKPGVYTRVTAYLDWIRQQTGI 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	93/245 (38%)
TMPRSS11D	NP_004253.1	SEA	48..143	CDD:279699
		Tryp_SPc	186..412	CDD:214473	92/243 (38%)
		Tryp_SPc	187..415	CDD:238113	93/245 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BKY1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810