DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and PRSS27

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_114154.1	Gene:	PRSS27 / 83886	HGNCID:	15475	Length:	290	Species:	Homo sapiens

Alignment Length:	289	Identity:	94/289 - (32%)
Similarity:	138/289 - (47%)	Gaps:	70/289 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1435 STECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHC--- 1496
            :|.|| ||.:.: |:|||:.:..|.:||||.::.:      ..:.|||.||..::|:|||||
Human    23 ATACG-RPRMLN-RMVGGQDTQEGEWPWQVSIQRN------GSHFCGGSLIAEQWVLTAAHCFRN 79

  Fly  1497 -----------------QPGFLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFEND 1544
                             |||                    ..::...|::|..:..|.......|
Human    80 TSETSLYQVLLGARQLVQPG--------------------PHAMYARVRQVESNPLYQGTASSAD 124

  Fly  1545 LALLELDSPVQFDTHIVPICMPNDVADF-TGRMATVTGWGRLKYGGGVPS--VLQEVQVPIIENS 1606
            :||:||::||.|..:|:|:|:|:....| ||....|||||.......:|.  :||::.||||:..
Human   125 VALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTP 189

  Fly  1607 VCQEMFH---TAGHN-KKILTSFLCAGYANGQKDSCEGDSGGPLV-------LQRPDGRYELAGT 1660
            .|..::.   ..|:. |.|....||||:..|:||:|:||||||||       ||        ||.
Human   190 KCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQ--------AGV 246

  Fly  1661 VSHGIKCAAPYLPGVYMRTTFYKPWLRSI 1689
            :|.|..||....||||:|.|.:..|:..|
Human   247 ISWGEGCARQNRPGVYIRVTAHHNWIHRI 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	87/273 (32%)
PRSS27	NP_114154.1	Tryp_SPc	34..272	CDD:214473	87/271 (32%)
PRSS27	NP_114154.1	Tryp_SPc	36..275	CDD:238113	87/272 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910