DRSC/TRiP Functional Genomics Resources

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Protein Alignment flz and TMPRSS2

DIOPT Version :9

Sequence 1:NP_001137622.1 Gene:flz / 35902 FlyBaseID:FBgn0286782 Length:1693 Species:Drosophila melanogaster
Sequence 2:NP_001128571.1 Gene:TMPRSS2 / 7113 HGNCID:11876 Length:529 Species:Homo sapiens


Alignment Length:304 Identity:91/304 - (29%)
Similarity:141/304 - (46%) Gaps:51/304 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly  1410 GGANGRKIHSTSRTLPTPNLAFHSPSTE-----------CGVRPH-VKSGRIVGGKGSTFGAYPW 1462
            |..:..|:::::..:......:||.:..           |||..: .:..|||||:.:..||:||
Human   242 GSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPW 306

  Fly  1463 QVLVRESTWLGLFTKN--KCGGVLITSRYVITAAHC------QPGFLASLVAVMGE-FDISGDLE 1518
            ||        .|..:|  .|||.:||..:::|||||      .|....:...::.: |...|   
Human   307 QV--------SLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYG--- 360

  Fly  1519 SKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVADFTGRM------A 1577
                ....|::||.|..||..|..||:||::|..|:.|:..:.|:|:||     .|.|      .
Human   361 ----AGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPN-----PGMMLQPEQLC 416

  Fly  1578 TVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDS 1642
            .::|||..:..|....||...:|.:||...|...:   .::..|..:.:|||:..|..|||:|||
Human   417 WISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRY---VYDNLITPAMICAGFLQGNVDSCQGDS 478

  Fly  1643 GGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWL 1686
            |||||..: :..:.|.|..|.|..||..|.||||.....:..|:
Human   479 GGPLVTSK-NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
flzNP_001137622.1 PRK14948 <272..452 CDD:237862
PRK11633 <365..>439 CDD:236940
PRK10263 <547..>1005 CDD:236669
PHA03247 <792..1096 CDD:223021
Tryp_SPc 1449..1689 CDD:238113 83/253 (33%)
TMPRSS2NP_001128571.1 DUF3824 <44..91 CDD:289625
LDLa 150..185 CDD:238060
SRCR_2 190..283 CDD:292133 5/40 (13%)
Tryp_SPc 292..521 CDD:214473 83/252 (33%)
Tryp_SPc 293..524 CDD:238113 83/253 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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