DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and st14a

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_001035441.2	Gene:	st14a / 678603	ZFINID:	ZDB-GENE-030131-6496	Length:	834	Species:	Danio rerio

Alignment Length:	845	Identity:	204/845 - (24%)
Similarity:	328/845 - (38%)	Gaps:	208/845 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   952 YDQPSAPSAS--YDQLAPMPSLNYNEQHASSPGRKPSTAKPISTSYVTGPSTPRPPATVDYHYDN 1014
            |:.|.:|...  .|:::....|.|:|            :..:|..|||.........:|..:|::
Zfish    94 YENPQSPEFQNLADKVSTQLKLMYSE------------SSQLSKYYVTSRVQAFSEGSVIAYYES 146

  Fly  1015 ---VPPLFMADDKLDAFIQSTAENI-------VGSTPGN-YQPPLVATASTPAYAHRPTSSGSYG 1068
               ||....|  .:|..:.:.:|..       |....|: ....:|::|.......:..||..|.
Zfish   147 EFAVPAAHEA--AVDQAVSNLSEKYSSGKARKVSEQQGSLVLDSVVSSALDKRLISKARSSTRYN 209

  Fly  1069 HKKPGFVQ----INGTPKPPRPTVL-----ITPKPTAINLVTYSSLSDDSNKLASSTSSYVTGRP 1124
            .....||:    ..|.|..|.|:..     :...|..:..:|:.:.:.:.|
Zfish   210 KHTSRFVEDIIFSPGFPDSPYPSNTFVQWQLRGDPDHVLKLTFDTFNLEQN-------------- 260

  Fly  1125 GVQGVSSNDF----------------KDPGYFG-SSPVHVAFTQSTTEAVYAVPSDDKPAFPGYF 1172
                 .||||                :..||:. |.|  ::|..|....:..:.::::.|:||:.
Zfish   261 -----CSNDFLRVYDSLVALDKFIMAEKCGYYSPSDP--LSFISSRNVMLVTLVTNEEGAYPGFR 318

  Fly  1173 GPTPSYPAFSVPGEKVGQNVMEETYTSPNDFVNFPPVRNPNLNMSAASSAVTSDLDLSTPA--FV 1235
            .......|.:..|..:|.:.:   :|||    |||....||         :|....:..||  |:
Zfish   319 ARVSQIQAVTCGGRMIGNSGI---FTSP----NFPDYYPPN---------ITCQWYIEVPAGKFI 367

  Fly  1236 EDVVLKDKMHTLVHKLVASLQGNFEALADMIEEPGSNK-------TVATYQAGAGGTAKPVRVVT 1293
            :   ||      ..|::.|.  ..|...|.:|..|.:|       |:.|..:...    .||.|:
Zfish   368 K---LK------FPKIMVST--GSECHGDFVEVVGQSKLCGQQLNTIVTVNSNTA----TVRFVS 417

  Fly  1294 TRKPV-RTATTTRPKVTTKKPVTRVTTKAPNKKTSAVSTTTRKPATR--------------RTTV 1343
            ....| |..:.|....:...|...:.. ..||:..       ||:.|              ....
Zfish   418 DSSNVDRGFSATFEDYSPSDPCQDLFL-CNNKRCV-------KPSMRCDGWNDCGDTSDEQNCQC 474

  Fly  1344 AAKVTTTTRRPATKKPTRRVSSTV-----KTTTVSSARPAD------DEIVDEEDEEDVNPNPSD 1397
            .||:...  :....||.......|     .|..::....||      |:.:.|:.:.|...:.:|
Zfish   475 DAKMIQC--KNGLCKPMFWRCDGVDDCGDSTDELNCGCRADQFKCKNDKCISEKQKCDGKDDCND 537

  Fly  1398 NEIDQGAT------LSSYGGANGRKIHSTSRTLPTPNL--------AFHSPSTECGVRPHVKSGR 1448
            ...::|..      :|::...|.:.|     |.|.|..        .....:..||.:.:.|| |
Zfish   538 GSDEEGCARTDSCLVSTFLCGNSKCI-----TKPNPECDGQDDCGDNSDESNCNCGTKAYKKS-R 596

  Fly  1449 IVGGKGSTFGAYPWQVLVRESTWLGLFTKN---KCGGVLITSRYVITAAHC----------QPGF 1500
            ||||:.:..|.:||||        .|..||   .|||.:|..|:::|||||          |||.
Zfish   597 IVGGQDAFEGEFPWQV--------SLHIKNIAHVCGGSIINERWIVTAAHCVQDDVKIKYSQPGT 653

  Fly  1501 LASLVAVMGEFDISGDLESKRSVTKN-VKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPIC 1564
            ....:.:..:.|       |.:.||. :|:||.|..|:..|::||:||:|::|||.|...|.|:|
Zfish   654 WEVFLGLHSQKD-------KLTATKRLLKQVIPHPYYNAYTYDNDIALMEMESPVTFSDTIRPVC 711

  Fly  1565 MPNDVADF-TGRMATVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCA 1628
            :|.....| .|....::|||..:.||...:|||:.:|.||.::||.::.     ..:|.:...||
Zfish   712 LPTATDTFPAGTSVFISGWGATREGGSGATVLQKAEVRIINSTVCNQLM-----GGQITSRMTCA 771

  Fly  1629 GYANGQKDSCEGDSGGPLVLQRPDG-RYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSITGV 1692
            |..:|..|:|:|||||||..  |.| |..|||.||.|..||....||:|.....::.|::..|||
Zfish   772 GVLSGGVDACQGDSGGPLSF--PSGKRMFLAGVVSWGDGCARRNKPGIYSNVPKFRAWIKEKTGV 834

Fly 1693 1692
Zfish 835 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669	11/54 (20%)
		PHA03247	<792..1096	CDD:223021	32/165 (19%)
		Tryp_SPc	1449..1689	CDD:238113	92/255 (36%)
st14a	NP_001035441.2	SEA	77..168	CDD:279699	17/87 (20%)
		CUB	219..322	CDD:238001	20/123 (16%)
		CUB	329..431	CDD:238001	31/132 (23%)
		LDLa	443..472	CDD:238060	5/36 (14%)
		LDLa	474..508	CDD:238060	6/35 (17%)
		LDLa	510..544	CDD:238060	6/33 (18%)
		LDLa	550..585	CDD:238060	6/39 (15%)
		Tryp_SPc	596..828	CDD:214473	92/253 (36%)
		Tryp_SPc	597..831	CDD:238113	92/255 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3236
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910