DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and PRSS22

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_071402.1	Gene:	PRSS22 / 64063	HGNCID:	14368	Length:	317	Species:	Homo sapiens

Alignment Length:	284	Identity:	95/284 - (33%)
Similarity:	151/284 - (53%)	Gaps:	39/284 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1424 LPTPNLAFHSPSTECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSR 1488
            :|.|      |:  || :|. :..|:|||:.||...:||.|.::::      ..:.|.|.|:|||
Human    35 IPVP------PA--CG-KPQ-QLNRVVGGEDSTDSEWPWIVSIQKN------GTHHCAGSLLTSR 83

  Fly  1489 YVITAAHC------QPGFLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFEN---- 1543
            :|||||||      :| :|.|:  ::|.:.:..  ...||....|..|..|..|   :::.
Human    84 WVITAAHCFKDNLNKP-YLFSV--LLGAWQLGN--PGSRSQKVGVAWVEPHPVY---SWKEGACA 140

  Fly  1544 DLALLELDSPVQFDTHIVPICMPNDVADF-TGRMATVTGWGRLKYGGGV--PSVLQEVQVPIIEN 1605
            |:||:.|:..:||...::|||:|:..... ......::|||.::.|..:  |..||:::||||::
Human   141 DIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDS 205

  Fly  1606 SVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAP 1670
            .||..::........|....|||||..|::|:|.|||||||:.| .||.:.|||.:|.|..||..
Human   206 EVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQ-VDGAWLLAGIISWGEGCAER 269

  Fly  1671 YLPGVYMRTTFYKPWLRSIT-GVK 1693
            ..||||:..:.::.|:..|. ||:
Human   270 NRPGVYISLSAHRSWVEKIVQGVQ 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	85/252 (34%)
PRSS22	NP_071402.1	Tryp_SPc	50..288	CDD:238113	85/252 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910