DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and F12

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_067464.2	Gene:	F12 / 58992	MGIID:	1891012	Length:	597	Species:	Mus musculus

Alignment Length:	322	Identity:	100/322 - (31%)
Similarity:	143/322 - (44%)	Gaps:	49/322 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1382 IVDEEDEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGVRPHVKS 1446
            :|.|..||    :||     |..:||.  ..|....|.||  |...|      :..||.|  .:.
Mouse   304 VVPESQEE----SPS-----QAPSLSH--APNDSTDHQTS--LSKTN------TMGCGQR--FRK 347

  Fly  1447 G-----RIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHCQPGFLA--SL 1504
            |     |:|||..:..|::|:   :....|    ..|.|.|.||...:|:|||||.....|  .|
Mouse   348 GLSSFMRVVGGLVALPGSHPY---IAALYW----GNNFCAGSLIAPCWVLTAAHCLQNRPAPEEL 405

  Fly  1505 VAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFENDLALLEL-----DSPVQFDTHIVPIC 1564
            ..|:|:...:...|..:::.  |:...:|..:...|:::|||||.|     :|......|:.|:|
Mouse   406 TVVLGQDRHNQSCEWCQTLA--VRSYRLHEGFSSITYQHDLALLRLQESKTNSCAILSPHVQPVC 468

  Fly  1565 MPNDVADFTGR-MATVTGWGRLKYGGGVPSV-LQEVQVPIIENSVCQEMFHTAGHNKKILTSFLC 1627
            :|:..|..:.. :..|.|||....|....|. |||.|||.|....|.   ::..|...||...||
Mouse   469 LPSGAAPPSETVLCEVAGWGHQFEGAEEYSTFLQEAQVPFIALDRCS---NSNVHGDAILPGMLC 530

  Fly  1628 AGYANGQKDSCEGDSGGPLVLQRPDGRYELA--GTVSHGIKCAAPYLPGVYMRTTFYKPWLR 1687
            ||:..|..|:|:||||||||.:.....::|.  |.:|.|..|.....||||.....|..|::
Mouse   531 AGFLEGGTDACQGDSGGPLVCEEGTAEHQLTLRGVISWGSGCGDRNKPGVYTDVANYLAWIQ 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	80/250 (32%)
F12	NP_067464.2	FN2	41..88	CDD:238019
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		KR	217..295	CDD:294073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..338		14/50 (28%)
		Tryp_SPc	354..591	CDD:214473	80/248 (32%)
		Tryp_SPc	355..594	CDD:238113	80/250 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910