DRSC/TRiP Functional Genomics Resources

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Protein Alignment flz and TMPRSS4

DIOPT Version :9

Sequence 1:NP_001137622.1 Gene:flz / 35902 FlyBaseID:FBgn0286782 Length:1693 Species:Drosophila melanogaster
Sequence 2:XP_005271670.1 Gene:TMPRSS4 / 56649 HGNCID:11878 Length:494 Species:Homo sapiens


Alignment Length:361 Identity:93/361 - (25%)
Similarity:159/361 - (44%) Gaps:73/361 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1342 TVAAKVTTTTRRPATKKPTRRVSSTVKTTTVSSARPADDEIVDEEDEEDVNPNPSDNEIDQGATL 1406
            |.|...|...:...:.|||.|..                ||..::|.:.|....:..|:      
Human   132 TEALAETACRQMGYSSKPTFRAV----------------EIGPDQDLDVVEITENSQEL------ 174

  Fly  1407 SSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGVRPHVKSGRIVGGKGSTFGAYPWQVLVRESTW 1471
                    |..:|:...|....::.|  ...||  ..:|:.|:||.:.::..::||||.::..  
Human   175 --------RMRNSSGPCLSGSLVSLH--CLACG--KSLKTPRVVGVEEASVDSWPWQVSIQYD-- 225

  Fly  1472 LGLFTKNKCGGVLITSRYVITAAHCQPGFLASLVAVMGEFDI--------SGDLESKRSVTKNVK 1528
                .::.|||.::...:|:|||||          .....|:        |..|.|..|:.  |.
Human   226 ----KQHVCGGSILDPHWVLTAAHC----------FRKHTDVFNWKVRAGSDKLGSFPSLA--VA 274

  Fly  1529 RVIVHRQYDPA-TFENDLALLELDSPVQFDTHIVPICMPNDVADFTGRMAT---VTGWGRLKYGG 1589
            ::|: .:::|. ..:||:||::|..|:.|...:.|||:|....:.|  .||   :.|||..|..|
Human   275 KIII-IEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELT--PATPLWIIGWGFTKQNG 336

  Fly  1590 G-VPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDG 1653
            | :..:|.:..|.:|:::.|..   ...:..::....:|||...|..|:|:|||||||:.|  ..
Human   337 GKMSDILLQASVQVIDSTRCNA---DDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ--SD 396

  Fly  1654 RYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSI 1689
            ::.:.|.||.|..|..|..||||.:.:.|..|:.::
Human   397 QWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNV 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
flzNP_001137622.1 PRK14948 <272..452 CDD:237862
PRK11633 <365..>439 CDD:236940
PRK10263 <547..>1005 CDD:236669
PHA03247 <792..1096 CDD:223021
Tryp_SPc 1449..1689 CDD:238113 73/252 (29%)
TMPRSS4XP_005271670.1 LDLa 58..92 CDD:238060
SRCR_2 108..197 CDD:295335 16/96 (17%)
Tryp_SPc 204..429 CDD:214473 73/250 (29%)
Tryp_SPc 205..432 CDD:238113 73/252 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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