DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and tmprss13b

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	XP_005165399.1	Gene:	tmprss13b / 564693	ZFINID:	ZDB-GENE-090309-2	Length:	475	Species:	Danio rerio

Alignment Length:	501	Identity:	132/501 - (26%)
Similarity:	200/501 - (39%)	Gaps:	118/501 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1267 EEPGSNKTVATYQAGAGGTAKPVRVVTTRKPVRTATTTRPKVTTKKPVTRVTTKAPNKKTSAVST 1331
            |.|.|..:|.|.......:...:::::|.: |:.....:|......|.. |.|..|.::|.|||.
Zfish     7 EAPPSYDSVVTQNITPPPSYPSLQILSTTQ-VQPYYIPQPLPQIPAPHV-VETTVPQQRTQAVSY 69

  Fly  1332 TTRKPATRRTT-VAAKVTTT-----------------TRRPATKKPTRRVSSTVKTTTVSSARPA 1378
            .:::.....:| :||.|...                 :.|.|.       :.|...:.|:.....
Zfish    70 RSKRCCYGGSTGIAAVVVLVVIAVYLGVRYGPSLWAFSERDAE-------TDTCPGSAVNCDGRK 127

  Fly  1379 DDEIVDEEDE-------------------------EDVNPNPSDNEIDQ-GATLS-SYG------ 1410
            |..:..:|.:                         :..|.|.:|....| |...| |||
Zfish   128 DCSLGSDESQCVRIGTGNELQVLTSRSGSFLPVCAQGWNKNIADQTCQQLGFRQSYSYGVVKSNS 192

  Fly  1411 ----GANGRKIH------STSRTLPTPNLAFHSPSTECGVRPHVKSGRIVGGKGSTFGAYPWQVL 1465
                ..|.:.::      :||.:.|... :......:|| ||.| |.||:||..:..|.:|||..
Zfish   193 PMFQSVNSQLVNNIQGRVNTSSSCPDQQ-SVSLQCCDCG-RPPV-SSRIIGGSVAAEGHWPWQAS 254

  Fly  1466 VRESTWLGLFTKNKCGGVLITSRYVITAAHCQP----------------GFLASLVAVMGEFDIS 1514
                  |....|:.|||.|:...::||||||.|                ||::.|
Zfish   255 ------LHFQGKHSCGGSLVAPDFIITAAHCFPKETSGSQLPSNWKVYIGFVSQL---------- 303

  Fly  1515 GDLESKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVADF-TGRMAT 1578
                 |......||.:|:|.:|:|.|...|:|||:|:.|.   :.:.|||:|.....| ..:...
Zfish   304 -----KLPSPYYVKEIILHEKYNPTTKNYDIALLKLNKPA---SDVEPICLPVIGQTFPPAKQCW 360

  Fly  1579 VTGWGRLKYG-GGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDS 1642
            .||:|.::.| ..|.:.|.||.|.:|::|||..   ...:|.:|..:..|||...|.||||:|||
Zfish   361 TTGFGVIRQGSNSVSTSLMEVTVSLIDSSVCNS---PNVYNGEITENMQCAGDLRGGKDSCQGDS 422

  Fly  1643 GGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRS 1688
            ||||..:..||::.|.|..|.|..|.....||||.....|..|:.|
Zfish   423 GGPLACKSNDGQWFLTGVTSWGEGCGQVNRPGVYSDVAKYLMWIYS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	86/258 (33%)
tmprss13b	XP_005165399.1	SRCR_2	147..230	CDD:295335	13/83 (16%)
		Tryp_SPc	237..466	CDD:214473	85/255 (33%)
		Tryp_SPc	238..469	CDD:238113	86/258 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000