DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flz and PROC

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	269	Identity:	87/269 - (32%)
Similarity:	129/269 - (47%)	Gaps:	40/269 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1441 RPHVK----------SGRIVGGKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAH 1495
            |.|:|          ..|::.||.:..|..||||::.:|.     .|..||.|||...:|:||||
Human   309 RSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSK-----KKLACGAVLIHPSWVLTAAH 368

  Fly  1496 CQPGFLASLVAVMGEFDISGDLESKRSVTKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHI 1560
            |.......||. :||:|:.  ...|..:..::|.|.||..|..:|.:||:|||.|..|......|
Human   369 CMDESKKLLVR-LGEYDLR--RWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTI 430

  Fly  1561 VPICMPND-----VADFTGRMATVTGWGRLKYGGGVPS--------VLQEVQVPIIENSVCQEMF 1612
            ||||:|:.     ..:..|:...|||||   |......        ||..:::|::.::.|.|:.
Human   431 VPICLPDSGLAERELNQAGQETLVTGWG---YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM 492

  Fly  1613 HTAGHNKKILTSFLCAGYANGQKDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYM 1677
                 :..:..:.||||....::|:||||||||:|... .|.:.|.|.||.|..|...:..|||.
Human   493 -----SNMVSENMLCAGILGDRQDACEGDSGGPMVASF-HGTWFLVGLVSWGEGCGLLHNYGVYT 551

  Fly  1678 RTTFYKPWL 1686
            :.:.|..|:
Human   552 KVSRYLDWI 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	83/251 (33%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011
		FXa_inhibition	255..290	CDD:317114
		Tryp_SPc	328..563	CDD:238113	83/250 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910