DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment flz and PLAU

DIOPT Version :9

Sequence 1:	NP_001137622.1	Gene:	flz / 35902	FlyBaseID:	FBgn0286782	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens

Alignment Length:	309	Identity:	95/309 - (30%)
Similarity:	144/309 - (46%)	Gaps:	67/309 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1412 ANGRKIHSTSRTLPTPNLAFHSPSTECG---VRPHVKSGRIVGGKGSTFGAYPWQVLVRESTWLG 1473
            |:|:|..|     |...|.|     :||   :||..|   |:||:.:|....||        :..
Human   152 ADGKKPSS-----PPEELKF-----QCGQKTLRPRFK---IIGGEFTTIENQPW--------FAA 195

  Fly  1474 LFTKNK-------CGGVLITSRYVITAAHCQPGFL-----ASLVAVMGEFDISGDLESKRSVTKN 1526
            ::.:::       |||.||:..:||:|.||   |:     ...:..:|...::.:.:.:...  .
Human   196 IYRRHRGGSVTYVCGGSLISPCWVISATHC---FIDYPKKEDYIVYLGRSRLNSNTQGEMKF--E 255

  Fly  1527 VKRVIVHRQY--DPATFENDLALLELDSP----VQFDTHIVPICMPNDVAD--FTGRMATVTGWG 1583
            |:.:|:|:.|  |.....||:|||::.|.    .|....|..||:|:...|  | |....:||:|
Human   256 VENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQF-GTSCEITGFG 319

  Fly  1584 R-----LKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQKDSCEGDSG 1643
            :     ..|    |..|:...|.:|.:..||:..:   :..::.|..|||.....:.|||:||||
Human   320 KENSTDYLY----PEQLKMTVVKLISHRECQQPHY---YGSEVTTKMLCAADPQWKTDSCQGDSG 377

  Fly  1644 GPLV--LQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSIT 1690
            ||||  ||   ||..|.|.||.|..||....||||.|.:.:.||:||.|
Human   378 GPLVCSLQ---GRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHT 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flz	NP_001137622.1	PRK14948	<272..452	CDD:237862
		PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021
		Tryp_SPc	1449..1689	CDD:238113	81/266 (30%)
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056	95/309 (31%)
		Connecting peptide	152..177		11/34 (32%)
		Tryp_SPc	179..422	CDD:238113	81/266 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910